糖尿病和非糖尿病COVID-19患者凝血功能障碍和炎症的标志物。
Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19.
作者信息
Varikasuvu Seshadri Reddy, Varshney Saurabh, Dutt Naveen
机构信息
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, 814152, India.
All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India.
出版信息
J Thromb Thrombolysis. 2021 May;51(4):941-946. doi: 10.1007/s11239-020-02270-w.
Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean difference-SMD: 0.47, CI 0.17-0.77, p = 0.002), C-reactive protein (SMD = 0.53, CI 0.20-0.86, p = 0.002), interleukin-6 (SMD = 0.31, CI 0.09-0.52, p = 0.005), fibrinogen (SMD = 0.31, CI 0.09-0.54, p = 0.007) and D-dimers (SMD = 0.54, CI 0.16-0.91, p = 0.005) were significantly higher in diabetic COVID-19 cases as compared to non-diabetic COVID-19 patients, suggesting more susceptibility of diabetic COVID-19 patients to coagulation dysfunction and inflammatory storm.
比较了糖尿病和非糖尿病COVID-19患者的凝血功能障碍和炎症状态。计算了炎症和高凝标志物差异的标准化平均差（SMD）及其95%置信区间（CI）。与非糖尿病COVID-19患者相比，糖尿病COVID-19病例的血清铁蛋白水平（标准化平均差-SMD：0.47，CI 0.17-0.77，p = 0.002）、C反应蛋白（SMD = 0.53，CI 0.20-0.86，p = 0.002）、白细胞介素-6（SMD = 0.31，CI 0.09-0.52，p = 0.005）、纤维蛋白原（SMD = 0.31，CI 0.09-0.54，p = 0.007）和D-二聚体（SMD = 0.54，CI 0.16-0.91，p = 0.005）显著更高，表明糖尿病COVID-19患者更容易出现凝血功能障碍和炎症风暴。
Zotero 插件