Yu Hui, Wang Kai, Zhong Ping, Cheng Huai-Dong, Lv Xin-Yi, Yuan Li-Li
Department of Neurology, Affiliated Suzhou Municipal Hospital of Anhui Medical University, Suzhou, China.
Neuropsychological Laboratory, Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Cogn Behav Neurol. 2020 Sep;33(3):201-207. doi: 10.1097/WNN.0000000000000242.
Subjective cognitive decline (SCD) has been called the prodromal stage of amnestic mild cognitive impairment (aMCI); however, further investigation is needed to confirm this observation.
To define the relationship between SCD and aMCI.
In this case-control study, we used the feeling-of-knowing in episodic memory (FOK-EM) test to measure the memory-monitoring function of 40 adults with aMCI, 60 with SCD, and 55 healthy controls.
The recognition rates of FOK-EM (53.53% ± 7.82%; 55.12% ± 6.08%) and judgment accuracy of the aMCI and SCD groups (γ values 0.21 ± 0.11; 0.30 ± 0.16) were significantly lower than those of the control group (72.32% ± 5.14%; 0.57 ± 0.16) (F = 116.24, P < 0.01; F = 128.57, P < 0.01; F = 73.33, P < 0.01). The scores for correct decision/correct recognition (RR; 27.2 ± 6.43; 29.36 ± 5.16) and correct decision/false recognition (RF; 30.41 ± 5.06; 27.26 ± 4.37) of the aMCI and SCD groups were also significantly lower than those of the control group (49.35 ± 7.13; 11.16 ± 4.35) (FRR = 132.67, P < 0.01; FRF = 131.8, P < 0.01).
Mild clinical impairments in memory-monitoring function may precede clinically confirmed objective memory impairment in individuals with SCD.
主观认知下降（SCD）被认为是遗忘型轻度认知障碍（aMCI）的前驱阶段；然而，需要进一步研究来证实这一观察结果。
明确SCD与aMCI之间的关系。
在这项病例对照研究中，我们使用情景记忆知晓感（FOK-EM）测试来测量40例aMCI成人、60例SCD成人和55例健康对照者的记忆监测功能。
aMCI组和SCD组的FOK-EM识别率（53.53%±7.82%；55.12%±6.08%）和判断准确性（γ值0.21±0.11；0.30±0.16）显著低于对照组（72.32%±5.14%；0.57±0.16）（F=116.24，P<0.01；F=128.57，P<0.01；F=73.33，P<0.01）。aMCI组和SCD组的正确决策/正确识别得分（RR；27.2±6.43；29.36±5.16）和正确决策/错误识别得分（RF；30.41±5.06；27.26±4.37）也显著低于对照组（49.35±7.13；11.16±4.35）（FRR=132.67，P<0.01；FRF=131.8，P<0.01）。
SCD个体的记忆监测功能轻度临床损害可能先于临床确诊的客观记忆损害出现。
