急性角膜内皮移植排斥合并 COVID-19 感染。
Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection.
机构信息
Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.
出版信息
Cornea. 2021 Jan;40(1):123-124. doi: 10.1097/ICO.0000000000002556.
PURPOSE
To report a case of acute corneal endothelial graft rejection with the concurrent onset of coronavirus disease 2019 (COVID-19) symptoms.
METHODS
Case report.
RESULTS
A 31-year-old African American woman with a history of asthma, sleep apnea, obesity (body mass index of 40), and bilateral keratoconus was noted to have acute corneal endothelial graft rejection 3 months after uncomplicated penetrating keratoplasty of the left eye. The patient developed dysgeusia and subjective fever on the same day as ocular discomfort, and she was subsequently diagnosed with COVID-19 with only these 2 classic symptoms of the viral infection.
CONCLUSIONS
Severe acute respiratory syndrome coronavirus 2 is known to cause conjunctivitis and has demonstrated transmissibility through ocular secretions. Acute immune and inflammatory dysregulations have been seen in cases of COVID-19 through various mechanisms. COVID-19 infection may potentially compromise ocular immune privilege contributing to acute corneal graft rejection.
目的
报告一例伴 2019 年冠状病毒病（COVID-19）症状同时发生的急性角膜内皮移植排斥反应。
方法
病例报告。
结果
一名 31 岁的非裔美国妇女，有哮喘、睡眠呼吸暂停、肥胖（体重指数为 40）和双侧圆锥角膜病史，左眼穿透性角膜移植术后 3 个月出现急性角膜内皮移植排斥反应。患者在眼部不适的同一天出现味觉障碍和主观发热，随后仅出现这 2 种病毒感染的典型症状被诊断为 COVID-19。
结论
已知严重急性呼吸综合征冠状病毒 2 可引起结膜炎，并已通过眼部分泌物证明具有传染性。通过各种机制，在 COVID-19 病例中观察到急性免疫和炎症失调。COVID-19 感染可能会损害眼部免疫豁免，导致急性角膜移植排斥反应。
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