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急性角膜内皮移植排斥合并 COVID-19 感染。

Acute Corneal Endothelial Graft Rejection With Coinciding COVID-19 Infection.

机构信息

Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.

出版信息

Cornea. 2021 Jan;40(1):123-124. doi: 10.1097/ICO.0000000000002556.

Abstract

PURPOSE

To report a case of acute corneal endothelial graft rejection with the concurrent onset of coronavirus disease 2019 (COVID-19) symptoms.

METHODS

Case report.

RESULTS

A 31-year-old African American woman with a history of asthma, sleep apnea, obesity (body mass index of 40), and bilateral keratoconus was noted to have acute corneal endothelial graft rejection 3 months after uncomplicated penetrating keratoplasty of the left eye. The patient developed dysgeusia and subjective fever on the same day as ocular discomfort, and she was subsequently diagnosed with COVID-19 with only these 2 classic symptoms of the viral infection.

CONCLUSIONS

Severe acute respiratory syndrome coronavirus 2 is known to cause conjunctivitis and has demonstrated transmissibility through ocular secretions. Acute immune and inflammatory dysregulations have been seen in cases of COVID-19 through various mechanisms. COVID-19 infection may potentially compromise ocular immune privilege contributing to acute corneal graft rejection.

摘要

目的

报告一例伴 2019 年冠状病毒病(COVID-19)症状同时发生的急性角膜内皮移植排斥反应。

方法

病例报告。

结果

一名 31 岁的非裔美国妇女,有哮喘、睡眠呼吸暂停、肥胖(体重指数为 40)和双侧圆锥角膜病史,左眼穿透性角膜移植术后 3 个月出现急性角膜内皮移植排斥反应。患者在眼部不适的同一天出现味觉障碍和主观发热,随后仅出现这 2 种病毒感染的典型症状被诊断为 COVID-19。

结论

已知严重急性呼吸综合征冠状病毒 2 可引起结膜炎,并已通过眼部分泌物证明具有传染性。通过各种机制,在 COVID-19 病例中观察到急性免疫和炎症失调。COVID-19 感染可能会损害眼部免疫豁免,导致急性角膜移植排斥反应。

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