Soifer Matias, Nguyen Nam V, Leite Ryan, Fernandes Josh, Kodati Shilpa
National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Vaccines (Basel). 2022 Oct 22;10(11):1776. doi: 10.3390/vaccines10111776.
To report a rare case of a patient with two recurrent episodes of Multiple Evanescent White Dot Syndrome (MEWDS) associated with the second dose and second booster of the mRNA-1273 COVID-19 vaccine (Moderna), and to perform a literature review on COVID-19-vaccine-associated MEWDS. A 31-year-old female was evaluated for a temporal scotoma and photopsias that started two weeks after the second dose of the Moderna COVID-19 vaccine. Dilated fundus findings were remarkable for unilateral, small whitish-yellow dots scattered around posterior pole of the left eye, consistent with a diagnosis of MEWDS. The symptoms resolved three months later without treatment. Approximately one year after the first vaccine, the patient received the second Moderna COVID-19 vaccine booster and experienced a recurrence of symptoms with an enlarged scotoma and similar examination findings. The patient was treated with a course of systemic corticosteroids with subsequent clinical improvement. Although uveitis following COVID-19 vaccines is rare, our case highlights a need for increased awareness amongst practitioners regarding COVID-19-vaccine-associated onset or recurrence of ocular inflammatory diseases.
报告1例与mRNA-1273新冠疫苗（Moderna）第二剂及第二剂加强针相关的复发性多发性一过性白点综合征（MEWDS）患者，并对新冠疫苗相关的MEWDS进行文献综述。一名31岁女性在接种Moderna新冠疫苗第二剂两周后，因出现颞侧暗点和闪光感接受评估。散瞳眼底检查发现，左眼后极部散在单侧、小的黄白色点状病变，显著异常，符合MEWDS诊断。症状在未治疗的情况下3个月后缓解。首次接种疫苗约一年后，该患者接种了第二剂Moderna新冠疫苗加强针，症状复发，暗点扩大，检查结果相似。患者接受了一个疗程的全身皮质类固醇治疗，随后临床症状改善。尽管新冠疫苗接种后葡萄膜炎很少见，但我们的病例强调临床医生需要提高对新冠疫苗相关眼部炎性疾病发病或复发的认识。
