Fischer M, Kempers B, Tschepke H D, Spitz J
Institut für Nuklearmedizin, Städtische Klinken, Kassel.
Radiologe. 1988 Apr;28(4):179-83.
Osteoporosis is becoming recognized as a major social and economical health problem. Bone mineral content (BMC) depends on many hormonal and metabolic factors. The pathophysiological mechanism of the loss of bone mass is still unclear. For preventive diagnosis and treatment of osteoporosis, quantitative technology is required that will measure BMC with high precision and reproducibility. Nuclear medical methods permit the BMC of the appendicular skeleton to be measured by single photon absorptiometry. Whole-body BMC, as well as spine and femur BMC, can be measured by dual photon absorptiometry. The results from both procedures are reasonably precise and correlate well with the ash weight of isolated bone. The radiation exposure level in both SPA and DPA is low. SPA and DPA may be used for cost-effective screening of high-risk patients to predict the likelihood of future fractures and control osteoporosis therapy.
骨质疏松症正逐渐被视为一个重大的社会和经济健康问题。骨矿物质含量（BMC）取决于许多激素和代谢因素。骨质流失的病理生理机制仍不清楚。为了对骨质疏松症进行预防性诊断和治疗，需要能够高精度且可重复地测量BMC的定量技术。核医学方法可通过单光子吸收法测量四肢骨骼的BMC。全身BMC以及脊柱和股骨BMC可通过双能光子吸收法测量。这两种方法的结果都相当精确，并且与分离骨骼的骨灰重量相关性良好。单光子吸收法（SPA）和双能光子吸收法（DPA）的辐射暴露水平都很低。SPA和DPA可用于对高危患者进行经济有效的筛查，以预测未来骨折的可能性并控制骨质疏松症的治疗。
