Division of Hematology-Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Division of Pathology & Laboratory Medicine, Children's National Medical Center, Washington, DC, USA; Departments of Pathology & Pediatrics, The George Washington University Health Sciences, Washington, DC, USA.
Semin Hematol. 2020 Apr;57(2):65-72. doi: 10.1053/j.seminhematol.2020.07.003. Epub 2020 Jul 27.
Over 400,000 units of blood and blood products are transfused to pediatric patients annually, yet only sparse high-quality data exist to guide the preparation and administration of blood products in this population. The direct application of data from studies in adult patients should be undertaken with caution, as there are dissimilarities in the pathology and physiology between adult and pediatric patients. We provide an overview of available evidence in the field of pediatric transfusion medicine, summarizing indications for blood product transfusion, thresholds for transfusion and indications for blood product modifications.
每年有超过 40 万单位的血液和血液制品用于儿科患者，但仅有少量高质量数据可用于指导该人群的血液制品制备和管理。由于成人和儿科患者的病理生理学存在差异，直接应用成人患者研究中的数据应谨慎进行。我们提供了儿科输血医学领域现有证据的概述，总结了血液制品输注的适应证、输血阈值和血液制品改良的适应证。
