U.S. Navy, San Diego, CA, USA.
Department of Oral Medicine, University of Pennsylvania, Penn Dental Medicine, 240 South 40th Street, Room 206, Schattner Building, Philadelphia, PA 19104, USA.
Dermatol Clin. 2020 Oct;38(4):467-476. doi: 10.1016/j.det.2020.05.007. Epub 2020 Aug 11.
Allergic contact hypersensitivity reactions of the oral mucosa pose a significant medical concern for some patients. Oral hypersensitivity reactions can result from a vast number of allergenic chemicals, but occur commonly from dental materials, flavorings, and preservatives. Clinical presentation is varied and often overlaps with other oral conditions, complicating their diagnosis and management. The most common clinical entities associated with oral hypersensitivity reactions are oral lichenoid reactions and allergic contact cheilitis. In addition to reviewing these conditions and their most common corresponding allergens, this article summarizes the pathogenesis of oral hypersensitivity reactions and addresses patch testing pearls.
口腔黏膜过敏性接触超敏反应对某些患者来说是一个重大的医学问题。口腔超敏反应可能由大量的过敏原化学物质引起，但常见于牙科材料、调味料和防腐剂。临床表现多种多样，常与其他口腔疾病重叠，使诊断和管理变得复杂。与口腔超敏反应相关的最常见临床实体是口腔类扁平苔藓样反应和过敏性接触性唇炎。除了回顾这些情况及其最常见的相应过敏原外，本文还总结了口腔超敏反应的发病机制，并介绍了斑贴试验的要点。
