Division of Oral Medicine, Tufts University School of Dental Medicine, 1 Kneeland Street, Boston, MA 02111, USA.
Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA.
Dermatol Clin. 2020 Oct;38(4):523-533. doi: 10.1016/j.det.2020.05.012. Epub 2020 Aug 11.
Adverse reactions to medications are common and may have a variety of clinical presentations in the oral cavity. Targeted therapies and new biologic agents have revolutionized the treatment of cancers, autoimmune diseases, and inflammatory and rheumatologic diseases but have also been associated with adverse events in the oral cavity. This review describes the most common clinical presentations of oral mucosal reactions to medications, namely hyposalivation, lichenoid reactions, ulcers, bullous disorders, pigmentation, fibrovascular hyperplasia, reactive keratosis, dysesthesia, osteonecrosis, infection, angioedema, and malignancy.
药物不良反应很常见，在口腔中可能有多种临床表现。靶向治疗和新型生物制剂彻底改变了癌症、自身免疫性疾病以及炎症和风湿性疾病的治疗方法，但也与口腔内的不良事件有关。本文描述了药物引起的口腔黏膜反应的最常见临床表现，即唾液分泌减少、类扁平苔藓样反应、溃疡、大疱性疾病、色素沉着、纤维血管性增生、反应性角化病、感觉异常、骨坏死、感染、血管性水肿和恶性肿瘤。
