Frankenhaeuser Freja, Söder Birgitta, Källmén Håkan, Korpi Esa R, Meurman Jukka H
Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Front Pharmacol. 2023 Mar 13;14:1146475. doi: 10.3389/fphar.2023.1146475. eCollection 2023.
Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic health connections. We hypothesized that periodontitis links to purchases of medicines later in life. The study cohort consisted of 3,276 individuals from the greater Stockholm area, Sweden. Of them, 1,655 were clinically examined at baseline. Patients were followed-up for >35 years, using the national population and patient registers. The burden of systemic diseases and purchases of medicines were statistically analyzed comparing patients with ( = 285) and without ( = 1,370) periodontitis. The results showed that patients with periodontitis had purchased more of certain medications than non-periodontitis patients. Periodontitis patients purchased significantly more drugs used in diabetes ( = 0.035), calcium channel blockers ( = 0.016), drugs acting on the renin-angiotensin system ( = 0.024), and nervous system drugs ( = 0.001). Hence, patients with periodontitis indeed had purchased specific medications statistically significantly more than the periodontally healthy ones. This indicates that periodontitis, over time, might increase the risk for systemic diseases with the subsequent need for medication.
用于治疗疾病的药物也会影响口腔健康。我们调查了1985年基线时患有/未患有牙周炎与长期购药之间的关联。该研究范式属于口腔健康与全身健康的联系。我们假设牙周炎与生命后期的购药有关。研究队列由来自瑞典大斯德哥尔摩地区的3276人组成。其中，1655人在基线时接受了临床检查。利用国家人口和患者登记册对患者进行了超过35年的随访。对患有（n = 285）和未患有（n = 1370）牙周炎的患者的全身疾病负担和购药情况进行了统计学分析。结果显示，患有牙周炎的患者比未患牙周炎的患者购买了更多的某些药物。牙周炎患者购买用于治疗糖尿病的药物（p = 0.035）、钙通道阻滞剂（p = 0.016）、作用于肾素-血管紧张素系统的药物（p = 0.024）和神经系统药物（p = 0.001）的数量显著更多。因此，患有牙周炎的患者确实比牙周健康的患者在统计学上显著购买了更多特定药物。这表明随着时间的推移，牙周炎可能会增加患全身疾病的风险，进而需要用药。
