评估重复性神经刺激试验中 Lambert-Eaton 肌无力综合征的运动单位复合动作电位幅度恢复时间在不同运动或测试之间的差异。
Assessment of the compound muscle action potential amplitude return time between exercises or tests in the repetitive nerve stimulation test for Lambert-Eaton myasthenic syndrome.
机构信息
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Muscle Nerve. 2020 Dec;62(6):742-745. doi: 10.1002/mus.27060. Epub 2020 Sep 29.
INTRODUCTION
When performing postexercise facilitation (PEF) as part of the repetitive nerve stimulation (RNS) test in Lambert-Eaton myasthenic syndrome (LEMS), it is important to avoid any influence of the previous exercise or RNS test on the compound muscle action potential (CMAP) amplitude.
METHODS
To measure the CMAP amplitude return time (ART) to that at rest, a single CMAP was obtained every 30 seconds until the amplitude was within 5% of that at rest in three exercise periods (10, 20, and 30 seconds) and in 10-second postexercise (PE) 3-Hz RNS testing with 17 tests in 10 LEMS patients.
RESULTS
Adequate ART between tests is 150 seconds for 10-second exercise (Ex) and 10-second PE 3-Hz RNS test, 120 seconds for 20-second Ex, and 90 seconds for 30-second Ex.
DISCUSSION
We recommend 150 seconds as adequate ART between the PEF test and the next test when performing RNS test in LEMS.
简介
在 Lambert-Eaton 肌无力综合征（LEMS）的重复神经刺激（RNS）测试中进行运动后易化（PEF）时，重要的是要避免先前的运动或 RNS 测试对复合肌肉动作电位（CMAP）幅度的任何影响。
方法
为了测量 CMAP 幅度恢复时间（ART）恢复到静止时的幅度，在三个运动期（10、20 和 30 秒）和 10 秒运动后（PE）3Hz RNS 测试中的 10 秒内，每隔 30 秒获得一次单个 CMAP，进行了 17 次测试，共有 10 例 LEMS 患者。
结果
在 10 秒运动（Ex）和 10 秒 PE 3Hz RNS 测试中，进行下一次测试的足够 ART 为 150 秒；在 20 秒 Ex 中为 120 秒；在 30 秒 Ex 中为 90 秒。
讨论
当在 LEMS 中进行 RNS 测试时，我们建议在 PEF 测试和下一次测试之间保持 150 秒的足够 ART。
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