Li Danyang, Xu Lizhou, Wang Jing, Gautrot Julien E
School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
Institute of Bioengineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK.
Adv Healthc Mater. 2021 Mar;10(5):e2000953. doi: 10.1002/adhm.202000953. Epub 2020 Sep 6.
Responsive polymer brushes are a category of polymer brushes that are capable of conformational and chemical changes in response to external stimuli. They offer unique opportunities for the control of bio-nano interactions due to the precise control of chemical and structural parameters such as the brush thickness, density, chemistry, and architecture. The design of responsive brushes at the surface of nanomaterials for theranostic applications has developed rapidly. These coatings can be generated from a very broad range of nanomaterials, without compromising their physical, photophysical, and imaging properties. Although the use of responsive brushes for nanotheranostic remains in its early stages, in this review, the aim is to present how the systems developed to date can be combined to control sensing, imaging, and controlled delivery of therapeutics. The recent developments for such design and associated methods for the synthesis of responsive brushes are discussed. The responsive behaviors of homo polymer brushes and brushes with more complex architectures are briefly reviewed, before the applications of responsive brushes as smart delivery systems are discussed. Finally, the recent work is summarized on the use of responsive polymer brushes as novel biosensors and diagnostic tools for the detection of analytes and biomarkers.
响应性聚合物刷是一类能够响应外部刺激而发生构象和化学变化的聚合物刷。由于能够精确控制诸如刷层厚度、密度、化学性质和结构等化学和结构参数，它们为控制生物-纳米相互作用提供了独特的机会。用于治疗诊断应用的纳米材料表面响应性刷的设计发展迅速。这些涂层可以由非常广泛的纳米材料制成，而不会损害其物理、光物理和成像特性。尽管响应性刷在纳米治疗诊断中的应用仍处于早期阶段，但在本综述中，目的是介绍如何将迄今为止开发的系统结合起来以控制传感、成像和治疗药物的可控递送。讨论了这种设计的最新进展以及合成响应性刷的相关方法。在讨论响应性刷作为智能递送系统的应用之前，简要回顾了均聚物刷和具有更复杂结构的刷的响应行为。最后，总结了关于使用响应性聚合物刷作为检测分析物和生物标志物的新型生物传感器和诊断工具的最新工作。
