Weir M R, Saunders E
Department of Internal Medicine, University of Maryland Hospital, Baltimore 21201.
Am J Cardiol. 1988 Jun 15;61(16):46H-52H. doi: 10.1016/0002-9149(88)91105-8.
This article contrasts the characteristics of essential hypertension found in the black population with that seen in the nonblack population. Socioeconomic and pathophysiologic factors are discussed. Different pharmacologic classes of drugs are compared for their effectiveness in treating the black hypertensive patient. Because black hypertensives tend to have salt-sensitive, low-renin hypertension coupled with decreased cardiac output and high peripheral vascular resistance, an ideal antihypertensive should have natriuretic effects but also the physiologic capability of reducing vascular resistance. Such an ideal hypertensive drug would be able to lower systemic blood pressure while improving organ perfusion and function.
本文对比了黑人人群中原发性高血压的特征与非黑人人群中所见的特征。讨论了社会经济和病理生理因素。比较了不同药理类别的药物在治疗黑人高血压患者方面的有效性。由于黑人高血压患者往往患有盐敏感性、低肾素性高血压，伴有心输出量降低和外周血管阻力升高，理想的抗高血压药物应具有利钠作用，还应具有降低血管阻力的生理能力。这样一种理想的抗高血压药物将能够降低全身血压，同时改善器官灌注和功能。
