Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Selangor Darul Ehsan 47500, Malaysia.
J Zhejiang Univ Sci B. 2020;21(9):745-748. doi: 10.1631/jzus.B2000278.
Piper betle (PB), also known as "betel" in Malay language, is a tropical Asian vine. PB leaves are commonly chewed by Asians along with betel quid. It contains phenols such as eugenol and hydroxychavicol along with chlorophyll, β-carotene, and vitamin C (Salehi et al., 2019). Extracts from PB leaves have various medicinal properties including anticancer, antioxidant, anti-inflammatory, and antibacterial effects (Salehi et al., 2019). Previous research has shown that PB induces cell cycle arrest at late S or G2/M phase and causes apoptosis at higher doses (Wu et al., 2014; Guha Majumdar and Subramanian, 2019). A combination of PB leaf extract has also been shown to enhance the cytotoxicity of the anticancer drug, 5-fluorouracil (5-FU), in cancer cells (Ng et al., 2014).
菝葜（PB），在马来语中也被称为“betel”，是一种热带亚洲藤本植物。亚洲人通常将 PB 叶与槟榔一起咀嚼。它含有丁香酚和对羟基肉桂酸等酚类化合物，以及叶绿素、β-胡萝卜素和维生素 C（Salehi 等人，2019 年）。PB 叶提取物具有多种药用特性，包括抗癌、抗氧化、抗炎和抗菌作用（Salehi 等人，2019 年）。先前的研究表明，PB 诱导细胞周期在晚期 S 或 G2/M 期停滞，并在较高剂量下引起细胞凋亡（Wu 等人，2014 年；Guha Majumdar 和 Subramanian，2019 年）。PB 叶提取物的组合也已被证明可增强抗癌药物 5-氟尿嘧啶（5-FU）在癌细胞中的细胞毒性（Ng 等人，2014 年）。
