VA Boston Healthcare System; Boston, Massachusetts, USA.
New England Geriatric Research Education and Clinical Center; Boston, Massachusetts, USA.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021 Sep;28(5):717-732. doi: 10.1080/13825585.2020.1817304. Epub 2020 Sep 6.
Metabolic syndrome (MetS) is a cluster of vascular risk factors that can impact cognition. Cognitive reserve (CR), specifically early operators of reserve (e.g., education), have not been explored in the relationship between MetS and cognition. Adults 45-90 years old (n = 149) underwent neuropsychological testing and evaluation for MetS. Exploratory and confirmatory factor analyses defined neuropsychological domains and created a CR score based on early operators of CR. Regression analyses examined the association among MetS, CR, and neuropsychological performance. CFA revealed two neuropsychological factors: Episodic Memory and Executive Functioning. Controlling for age and physical ability, MetS and CR were significant predictors of the Factors. With CR in the model, MetS became a non-significant predictor of Executive Functioning; CR and physical ability were the most significant predictors. CR and MetS significantly predicted Episodic Memory . The results are discussed in the context of neuroprotective factors and cognitive aging.
代谢综合征（MetS）是一组血管危险因素，可影响认知。认知储备（CR），特别是储备的早期作用者（例如，教育），在 MetS 和认知之间的关系中尚未得到探讨。45-90 岁的成年人（n=149）接受了神经心理学测试和 MetS 评估。探索性和验证性因素分析定义了神经心理学领域，并基于 CR 的早期作用者创建了 CR 分数。回归分析检查了 MetS、CR 和神经心理学表现之间的关联。CFA 显示了两个神经心理学因素：情节记忆和执行功能。控制年龄和身体能力后，MetS 和 CR 是这些因素的显著预测因子。在模型中加入 CR 后，MetS 成为执行功能的非显著预测因子；CR 和身体能力是最重要的预测因子。CR 和 MetS 显著预测了情节记忆。结果在神经保护因素和认知老化的背景下进行了讨论。
