Chair and Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Lublin, Poland.
Eur Rev Med Pharmacol Sci. 2020 Aug;24(16):8394-8401. doi: 10.26355/eurrev_202008_22636.
The TNM (Tumor, Node, Metastasis) classification of Union for International Cancer Control is a system describing the anatomical extent of the solid tumors that leads to staging and decision on the type of treatment. The latter TNM system (2017) as compared to the previous version (2010) has brought numerous changes. Our aim was to examine whether significant changes in the new TNM edition have altered the components of the TNM classification in patients and the stage of the disease to which they are ascribed.
The study is retrospective and is based on radiological examination reports and case reports of 100 patients of the Department of Pneumonology, Allergology and Oncology of the Medical University in Lublin, Poland. One hundred randomly selected patients, who were hospitalized at the Clinic between 2013 and 2018 with primary lung cancer were enrolled in the study. The chi-square test, Mann-Whitney U test, Kruskal-Wallis test and an appropriate post-hoc test were used in statistical analysis.
It was calculated that the T descriptor evaluated as per TNM in revision 8th in comparison to revision 7th changed in 41% of patients, the M descriptor - in 29% of patients, which resulted in change in staging in 11 patients. In spite of this scale amendments, only three patients could be treated differently because of the change in the stage of the disease.
Changing the treatment method, including withdrawal from surgery, can help avoid unnecessary treatment, but on the other hand, may potentially reduce the patient's chances of survival by depriving them of the possibility of radical treatment.
国际抗癌联盟的 TNM（肿瘤、淋巴结、转移）分类是一种描述实体瘤解剖范围的系统，可用于分期和治疗方案决策。与前一版本（2010 年）相比，后者（2017 年）TNM 系统带来了许多变化。我们的目的是检查新 TNM 版本中的重大变化是否改变了患者的 TNM 分类组成及其归属的疾病分期。
该研究是回顾性的，基于波兰卢布林医科大学肺病学、过敏学和肿瘤学系的 100 名患者的放射学检查报告和病例报告。本研究纳入了 100 名随机选择的患者，这些患者于 2013 年至 2018 年期间在该诊所因原发性肺癌住院。在统计分析中使用了卡方检验、Mann-Whitney U 检验、Kruskal-Wallis 检验和适当的事后检验。
据计算，与第 7 版相比，第 8 版 TNM 评估的 T 描述符在 41%的患者中发生变化，M 描述符在 29%的患者中发生变化，导致 11 名患者分期发生变化。尽管进行了这些量表修正，仅有 3 名患者因疾病分期的变化而需要进行不同的治疗。
改变治疗方法，包括放弃手术，可以帮助避免不必要的治疗，但另一方面，可能会通过剥夺患者根治性治疗的可能性，降低患者的生存机会。
