Department of Clinical Biochemistry, North Zealand Hospital, University of Copenhagen, Hilleroed, Denmark.
Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Int J Lab Hematol. 2021 Feb;43(1):52-60. doi: 10.1111/ijlh.13330. Epub 2020 Sep 7.
Hematological patients, receiving intensive chemotherapy (predominantly acute leukemia patients), have repeated postchemotherapy periods with severe bone marrow suppression. As a result, these patients require regular monitoring of the complete blood counts (CBC) for optimal patient care. To reduce the strain on the patient, there is a need for a point-of-care (POC) hematology device that provides rapid and reliable results both in general and in cytopenic samples and is suitable for outpatient clinics. We evaluated the HemoScreen device for the most used CBC parameter both overall and at the lower range.
The HemoScreen was compared with the Sysmex XN-9000 in 206 routine venous samples and 79 capillary bedside samples focusing on white blood cells (WBC), absolute neutrophil count (ANC), red blood cells (RBC), PLT and HGB.
The HemoScreen was less precise compared to the acceptance criteria set for larger and more advanced hematology instrument with a CV% 3.0-3.7 for WBCs, 3.6-8.4 for ANCs, 1.1-1.5 for RBCs, 2.5-4.4 for PLTs, and 1.7-2.3 for HGB. Correlation coefficient for all five parameters for the entire range was r >.95 and r >.90 at lower range for venous and capillary samples. Bias limits were within the CTCAE acceptance limits.
The HemoScreen provides rapid and accurate test results, for evaluation of WBC, PLT, and HGB, as well as at low concentrations for guiding transfusions and postchemotherapy treatment. The device is easy to operate and can measure both venous and capillary samples. Therefore, the HemoScreen is well suited for smaller outpatient clinics and potentially home use.
接受强化化疗（主要为急性白血病患者）的血液系统疾病患者在化疗后骨髓抑制严重，需要多次进行检查。因此，需要定期监测全血细胞计数（CBC），以确保为患者提供最佳护理。为了减少患者的负担，需要一种即时检测（POC）血液学设备，该设备在一般情况下和在细胞减少症样本中都能快速、可靠地提供结果，且适用于门诊。我们评估了 HemoScreen 设备在最常用的 CBC 参数方面的性能，包括整体参数和低值参数。
我们将 HemoScreen 与 Sysmex XN-9000 进行了比较，共评估了 206 例常规静脉样本和 79 例毛细血管床边样本，重点评估了白细胞（WBC）、绝对中性粒细胞计数（ANC）、红细胞（RBC）、血小板（PLT）和血红蛋白（HGB）。
与大型、更先进的血液学仪器的接受标准相比，HemoScreen 的精密度较差，WBC 的 CV%为 3.0-3.7，ANC 的 CV%为 3.6-8.4，RBC 的 CV%为 1.1-1.5，PLT 的 CV%为 2.5-4.4，HGB 的 CV%为 1.7-2.3。所有五个参数的整个范围内的相关系数 r>.95，静脉和毛细血管样本低值范围内的相关系数 r>.90。偏差限值在 CTCAE 接受限值内。
HemoScreen 可快速、准确地提供测试结果，可用于评估 WBC、PLT 和 HGB，还可在低值范围内用于指导输血和化疗后治疗。该设备易于操作，可测量静脉和毛细血管样本。因此，HemoScreen 非常适合小型门诊，也可能适合家庭使用。
