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[国家献血与血液保存计划的产科方面]

[Obstetrical aspects of the National Blood Donation and Blood Saving Program].

作者信息

Oláh Zsolt, Deli Tamás, Mühl Diána

机构信息

Általános Orvostudományi Kar, Aneszteziológiai és Intenzív Terápiás Klinika,Debreceni Egyetem, Debrecen.

Általános Orvostudományi Kar, Szülészeti és Nőgyógyászati Intézet,Debreceni Egyetem, Debrecen.

出版信息

Orv Hetil. 2020 Sep;161(37):1588-1598. doi: 10.1556/650.2020.31915.

DOI:10.1556/650.2020.31915
PMID:32894739
Abstract

The aims of the National Blood Donation and Blood Saving Program are to support the rational and judicious utilization of blood products and abolish irrational transfusion policy to improve patient safety. In addition to the general principles, this program has got some special obstetrical aspects. Obstetrical, especially the postpartum haemorrhages belong to the leading causes of maternal mortality worldwide. In developed countries, a trend in increasing incidence can be observed. Preparing for delivery includes some important elements such as optimization of hemoglobin level, routinely applied prophylactic or therapeutic iron supplementation and early screening and comprehensive care of patients with high risk of obstetrical bleeding. The main causes of peripartum bleeding are abruptio placentae, placenta praevia, uterine atony, retained tissue in the uterus, trauma during delivery, and haemostatic disorders or their combinations. To prevent postpartum bleeding, it is important to use the active management of the third stage of labour including prophylactic utilization of uterotonics as an essential element. Utilization of blood salvage techniques with adequate indications may be considered in cases of cesarean section or postpartum haemorhage. In cases of obstetrical haemorrhage, management of surgical bleeding has the main priority by the obstetrician. Secondary coagulopathy associated with massive bleeding should be managed by viscoelastic test-guided, individualized and factor concentrate-based algorithm, however, pregnancy-specific reference and target ranges must be used that are different from the non-pregnancy values. Obstetrical bleedings belong to the potentially preventable causes of death. Hopefully, the implementation of the National Blood Donation and Blood Saving Program in the field of obstetrics can decrease the associated morbidity and mortality further. Orv Hetil. 2020; 161(37): 1588-1598.

摘要

国家献血与血液节约计划的目标是支持合理、明智地使用血液制品,废除不合理的输血政策,以提高患者安全性。除了一般原则外,该计划还有一些特殊的产科方面。产科情况,尤其是产后出血是全球孕产妇死亡的主要原因之一。在发达国家,可以观察到发病率上升的趋势。分娩准备包括一些重要因素,如优化血红蛋白水平、常规应用预防性或治疗性铁补充剂,以及对产科出血高危患者进行早期筛查和全面护理。围产期出血的主要原因是胎盘早剥、前置胎盘、子宫收缩乏力、子宫内残留组织、分娩时的创伤以及止血障碍或它们的组合。为预防产后出血,积极管理第三产程很重要,包括预防性使用宫缩剂作为关键要素。在剖宫产或产后出血的情况下,可考虑在有适当指征时使用血液回收技术。在产科出血的情况下,产科医生应将手术出血的管理作为首要任务。与大量出血相关的继发性凝血障碍应通过黏弹性试验指导的、个体化的、基于凝血因子浓缩物的算法进行管理,然而,必须使用与非孕期值不同的特定于妊娠的参考值和目标范围。产科出血属于潜在可预防的死亡原因。希望国家献血与血液节约计划在产科领域的实施能够进一步降低相关的发病率和死亡率。《匈牙利医学周报》。2020年;161(37):1588 - 1598。

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