Kathrani A, Church D B, Brodbelt D C, Pegram C, O'Neill D G
Clinical Science and Services, Royal Veterinary College, North Mymms, Hatfield, AL9 7TA, UK.
Pathobiology and Population Science, Royal Veterinary College, North Mymms, Hatfield, AL9 7TA, UK.
J Small Anim Pract. 2020 Dec;61(12):723-731. doi: 10.1111/jsap.13214. Epub 2020 Sep 7.
To describe responses of cats prescribed a hydrolysed diet with or without concurrent medication for chronic vomiting and/or diarrhoea of undetermined aetiology.
Anonymised records of 512,213 cats under UK veterinary care in 2016 from the VetCompass database were searched using relevant terms for hydrolysed diets. The records of 5000 (90%) of 5569 cats with evidence of receiving a hydrolysed diet were randomly reviewed for gastrointestinal indication, prior and concurrent medication and response after hydrolysed dietary intervention. A poor response was defined as evidence of receiving antibiotic or glucocorticoid treatment for vomiting/diarrhoea at visits after the onset of the diet or death from gastrointestinal signs for at least 6 months follow-up.
Of 977 cats prescribed a hydrolysed diet for chronic vomiting/diarrhoea, 697 (71%) were first prescribed the diet without concurrent antibiotics or glucocorticoids while 280 (29%) first received the diet with these medications. Thirty-four per cent of cats in the former group and 61% in the latter had a poor response. Cats older than 6 years and cats prescribed antibiotic and/or glucocorticoid for vomiting/diarrhoea before and concurrently with the diet had higher odds of poor response.
Although variations in our observations may reflect severity of signs or prescribing habits of primary-care veterinary surgeons, our study suggests there is merit in trialling a hydrolysed diet first as a sole therapy in cats with chronic vomiting/diarrhoea when diagnostic investigations do not reveal a cause, before resorting to antibiotic and/or glucocorticoid therapy for cases that respond poorly.
描述给患有慢性呕吐和/或腹泻(病因不明)的猫喂食水解饮食(无论是否同时用药)后的反应。
使用与水解饮食相关的术语,在VetCompass数据库中搜索2016年英国兽医护理下的512,213只猫的匿名记录。对5569只猫中5000只(90%)有接受水解饮食证据的记录进行随机审查,以了解胃肠道指征、之前和同时使用的药物以及水解饮食干预后的反应。反应不佳定义为在开始饮食后就诊时因呕吐/腹泻接受抗生素或糖皮质激素治疗的证据,或在至少6个月的随访中因胃肠道症状死亡。
在977只因慢性呕吐/腹泻而喂食水解饮食的猫中,697只(71%)首次喂食该饮食时未同时使用抗生素或糖皮质激素,而280只(29%)首次接受该饮食时同时使用了这些药物。前一组中有34%的猫反应不佳,后一组中有61%的猫反应不佳。6岁以上的猫以及在饮食前和饮食时因呕吐/腹泻同时使用抗生素和/或糖皮质激素的猫反应不佳的几率更高。
尽管我们观察结果的差异可能反映了症状的严重程度或基层兽医外科医生的开药习惯,但我们的研究表明,对于慢性呕吐/腹泻的猫,在诊断性检查未发现病因时,先试用水解饮食作为单一疗法是有价值的,对于反应不佳的病例,再采用抗生素和/或糖皮质激素治疗。