Keith D. Wing Consulting, LLC, 122 Yardley Lane, Wilmington, DE, USA.
Pest Manag Sci. 2021 Aug;77(8):3617-3625. doi: 10.1002/ps.6075. Epub 2020 Oct 3.
Novel neuroactive insecticides are discovered/registered differently, have a lower value in use, and exert their physiological actions in manners distinct from neuroactive pharmaceuticals, but there are clear similarities in their biochemical modes of action. Insecticides are generally discovered using whole pest insect screens, and this eases difficulties in 'translational science' from laboratory to field, as opposed to pharmaceutical translation from biochemical or cell-based targets to animal models to human clinical trials to registered drug. This paper examines recent trends in pharmaceutical science and identifies some technologies which may represent complementary approaches to insecticide discovery screening and mode of action determination beyond the sound processes in common practice today. Examples will be drawn from nanoparticle delivery of neuroactives, unique ligand-polymer conjugates, proposed advances in insect cell culture following from pharmaceutical cell biology, and laboratory or organ-on-a-chip approaches. It is hoped that these concepts will stimulate novel thinking which may enable discovery of efficacious new neuroactive insecticides. © 2020 Society of Chemical Industry.
新型神经活性杀虫剂的发现/注册方式不同，在使用中的价值较低，并且其生理作用方式与神经活性药物不同，但它们在生化作用模式上有明显的相似之处。杀虫剂通常使用整只害虫屏幕进行发现，这简化了从实验室到现场的“转化科学”的困难，而不同于从生化或基于细胞的靶标到动物模型到人类临床试验到注册药物的药物转化。本文考察了药物科学的最新趋势，并确定了一些技术，这些技术可能代表了除当今常见实践中的合理过程之外的杀虫剂发现筛选和作用模式确定的互补方法。将从神经活性剂的纳米颗粒传递、独特的配体-聚合物缀合物、从药物细胞生物学中提出的昆虫细胞培养的进展以及实验室或器官芯片方法中提取示例。希望这些概念将激发新颖的思维，从而使有效的新型神经活性杀虫剂的发现成为可能。 © 2020 英国化学学会。
