Department of Child and Adolescent Psychiatry, Faculty of Medicine, Istanbul University, İstanbul, Turkey.
Department of Otorhinolaryngology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Int J Pediatr Otorhinolaryngol. 2020 Oct;137:110239. doi: 10.1016/j.ijporl.2020.110239. Epub 2020 Jul 10.
This study aimed to evaluate the effects of surgical intervention on quality of life, emotional/behavioural problems and school absenteeism in children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA.) METHOD: A total of 56 children aged between 4 and 12 years, diagnosed with PFAPA and undergoing tonsillectomy with/without adenoidectomy at a tertiary hospital were included in the study. The Questionnaire for Quality of Life Assessment for Children and Adolescents Parent Form (Kid-KINDL) and the Strengths and Difficulties Questionnaires (SDQ) were used to evaluate quality of life and emotional/behavioural problems, respectively. The cases were assessed before and three months after surgery.
The mean (SD) age of the children was 6.64 (3.03) years, and 58.9% (n = 33) were boys. The numbers of pre- and post-operative periodic fever episodes were 3.0 (1.7) and 0.6 (0.9) (p < 0.001), those for school absenteeism were 10.28 (5.53) and 2.85 (2.95) days (p < 0.001) and those for hospital presentations were 3.8 (2.5) and 1.1 (1.1) (p < 0.001), respectively, all of which were significantly lower in children with PFAPA at three months after the operation. The surgical procedures were effective in improving quality of life and emotional/behavioural problems, as evidenced by the significant differences between the pre- and post-treatment scores in outcome measures, including SDQ and Kid-KINDL (p < 0.001).
This study demonstrated that the surgical approach exhibited positive effects in terms of improving quality of life and reducing emotional/behavioural problems and school absenteeism in children with PFAPA.
本研究旨在评估手术干预对周期性发热、口疮性口炎、咽炎和颈部淋巴结炎（PFAPA）患儿生活质量、情绪/行为问题和缺课的影响。
本研究共纳入 56 名年龄在 4 至 12 岁之间、在一家三级医院接受扁桃体切除术联合/不联合腺样体切除术的 PFAPA 患儿。采用儿童青少年生活质量评估问卷家长版（Kid-KINDL）和长处与困难问卷（SDQ）分别评估生活质量和情绪/行为问题。在手术前和手术后 3 个月对患儿进行评估。
患儿的平均（SD）年龄为 6.64（3.03）岁，58.9%（n=33）为男性。术前和术后的周期性发热发作次数分别为 3.0（1.7）和 0.6（0.9）次（p<0.001），缺课天数分别为 10.28（5.53）和 2.85（2.95）天（p<0.001），就诊次数分别为 3.8（2.5）和 1.1（1.1）次（p<0.001），所有这些在手术后 3 个月的 PFAPA 患儿中均显著降低。手术程序在改善生活质量和情绪/行为问题方面是有效的，这可以从 SDQ 和 Kid-KINDL 等结局测量指标的治疗前后评分差异中得到证明（p<0.001）。
本研究表明，手术方法对改善 PFAPA 患儿的生活质量、减少情绪/行为问题和缺课具有积极作用。
