Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur, Montréal, Canada; Center for Medicine and Research in Sleep, Department of Neurology, Centre Hospitalier Universitaire de Nancy, Nancy, France.
Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur, Montréal, Canada.
Neurophysiol Clin. 2020 Oct;50(5):339-343. doi: 10.1016/j.neucli.2020.08.003. Epub 2020 Sep 4.
Sleepwalkers have consistently shown N3 sleep discontinuity, especially after sleep deprivation. In healthy subjects, sleep spindles activity has been positively correlated to sleep stability. We aimed to compare spindles density during N3 sleep between sleepwalkers and healthy controls.
Two cohorts of 10 and 21 adult sleepwalkers respectively controlled with 10 and 18 healthy volunteers underwent one baseline and one recovery sleep recording after 38h (cohort 1) and 25h (cohort 2) of sleep deprivation. For the two recordings, we performed an automatic detection of spindles (11-16Hz) from EEG signal during N3 sleep, restricted to the first sleep cycle and repeated for all cycles. For better interpretation of results, we extended the analysis to N2 sleep and we also measured the density of slow waves oscillation (SWO) (0.5-4Hz) during the same periods.
Compared to controls, sleepwalkers showed significantly lower spindle densities during N3 sleep considering the first sleep cycle (both cohorts) or all cycles (cohort 1). SWO densities did not differ (cohort 1) or were lower (cohort 2) for sleepwalkers. The effect of sleep deprivation did not interact with the effect of group on spindles and SWO densities.
This work suggests that the instability of N3 sleep inherent to sleepwalkers may be underpinned by a specific alteration of spindles activity.
梦游者的 N3 睡眠一直表现出不连续性，尤其是在睡眠剥夺后。在健康受试者中，睡眠梭形波活动与睡眠稳定性呈正相关。我们旨在比较梦游者和健康对照组在 N3 睡眠期间的梭形波密度。
两个队列，分别有 10 名和 21 名成年梦游者，由 10 名和 18 名健康志愿者控制，分别进行了一次基线和一次恢复睡眠记录，在 38 小时（队列 1）和 25 小时（队列 2）的睡眠剥夺后。对于这两次记录，我们从 EEG 信号中自动检测 N3 睡眠期间的梭形波（11-16Hz），限制在第一个睡眠周期内，并对所有周期进行重复。为了更好地解释结果，我们将分析扩展到 N2 睡眠，并在同一时期测量了慢波振荡（SWO）（0.5-4Hz）的密度。
与对照组相比，梦游者在考虑第一个睡眠周期（两个队列）或所有周期（队列 1）时，N3 睡眠期间的梭形波密度明显较低。SWO 密度没有差异（队列 1）或较低（队列 2）。睡眠剥夺的影响与组对梭形波和 SWO 密度的影响没有相互作用。
这项工作表明，梦游者 N3 睡眠的不稳定性可能是由梭形波活动的特定改变所支撑的。
