CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Biochem Soc Trans. 2020 Oct 30;48(5):2283-2293. doi: 10.1042/BST20200603.
Butanol is an important chemical and potential fuel. For more than 100 years, acetone-butanol-ethanol (ABE) fermentation of Clostridium strains has been the most successful process for biological butanol production. In recent years, other microbes have been engineered to produce butanol as well, among which Escherichia coli was the best one. Considering the crude oil price fluctuation, minimizing the cost of butanol production is of highest priority for its industrial application. Therefore, using cheaper feedstocks instead of pure sugars is an important project. In this review, we summarized butanol production from different renewable resources, such as industrial and food waste, lignocellulosic biomass, syngas and other renewable resources. This review will present the current progress in this field and provide insights for further engineering efforts on renewable butanol production.
丁醇是一种重要的化学物质和潜在燃料。100 多年来，利用梭菌菌株进行丙酮-丁醇-乙醇（ABE）发酵一直是生物丁醇生产最成功的工艺。近年来，其他微生物也被用于生产丁醇，其中大肠杆菌是最好的一种。考虑到原油价格波动，降低丁醇生产成本是其工业应用的首要任务。因此，使用较便宜的原料而不是纯糖是一个重要的项目。在本文综述中，我们总结了利用不同可再生资源生产丁醇的情况，如工业和食品废物、木质纤维素生物质、合成气和其他可再生资源。本文综述将介绍该领域的最新进展，并为进一步进行可再生丁醇生产的工程研究提供思路。
