Tchidjou Hyppolite Kuekou, Caron Fiorella, Ferec Adeline, Braun Karine, Hery Loic, Castelain Sandrine, Romeo Bernard
Pediatric Emergency Services.
Department of Pediatric Neurology.
Blood Coagul Fibrinolysis. 2020 Dec;31(8):575-577. doi: 10.1097/MBC.0000000000000954.
: It is now known that SARS-CoV-2 infection because of coronavirus is highly contagious and caused varying degrees of illness throughout the world. Hepatic dysfunction and the slight elevation of liver enzymes have been reported in cases of COVID-19 infection. Transient hyperphosphatasemia is a benign condition characterized by the elevation of serum alkaline phosphatase and the return to normal levels within weeks or months of first observation. We reported the first infant case of severe hyperphosphatasemia because of SARS-CoV-2 infection, in a 9-month-old child admitted to the Pediatric Covid-19 Unit of Amiens University Hospital. Given the hepatic tropism and COVID-19-related hyperinflammatory reactions, our case suggests that, an isolated severe hyperphosphatasemia in children with SARS-CoV-2 infection should increase the possibility of transient hyperphosphatasemia, even if is also demonstrated a classic natural history of the transient hyperphosphatasemia during viral infection, especially in SARS-CoV-2 infection.
现已知道，由冠状病毒引起的SARS-CoV-2感染具有高度传染性，并在全球范围内导致了不同程度的疾病。在COVID-19感染病例中，已报告出现肝功能障碍和肝酶轻度升高。短暂性高磷酸酶血症是一种良性病症，其特征为血清碱性磷酸酶升高，并在首次观察后的数周或数月内恢复至正常水平。我们报告了首例因SARS-CoV-2感染导致严重高磷酸酶血症的婴儿病例，该患儿为一名9个月大的儿童，入住亚眠大学医院儿科COVID-19病房。鉴于肝脏嗜性和与COVID-19相关的高炎症反应，我们的病例表明，SARS-CoV-2感染儿童中出现的孤立性严重高磷酸酶血症应增加短暂性高磷酸酶血症的可能性，即使在病毒感染（尤其是SARS-CoV-2感染）期间也表现出短暂性高磷酸酶血症的典型自然病程。
