John P. Murtha Cancer Center Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockledge Drive.
Eur J Cancer Prev. 2021 Jul 1;30(4):328-333. doi: 10.1097/CEJ.0000000000000625.
In the USA, brain cancer disproportionately affects young adults. The US military has a younger age structure than the general population and may have differential exposures related to brain cancer. This study aimed to compare the incidence rates of brain cancer in the active-duty military and general populations to provide clues for future etiologic research. The rates between military service branches were also compared.
The data for this study were from the Department of Defense's Automated Central Tumor Registry (ACTUR) and the National Cancer Institute's Surveillance, Epidemiology, and End Results 9 (SEER-9) registries. Age- and sex-adjusted incidence rates of malignant neuroepithelial brain cancer among adults 20-54 years of age from 1990-2013 were calculated and compared between the two populations, given as incidence rate ratios (IRRs) with 95% confidence intervals (CIs).
The age and sex-adjusted incidence rate for malignant neuroepithelial brain cancer was significantly lower in the active-duty population than in the US general population (IRR = 0.62, 95% CI, 0.56-0.68). The reduced incidence rate in the active-duty population was observed in men, all races, individuals 20-44 of age, and for all histological subtypes and time periods assessed. There were no significant differences in rates between the military service branches.
The incidence rates of neuroepithelial brain cancer were lower in the active-duty military population than the US general population. This study highlights the need for more research to enhance our understanding of variations in brain cancer incidence between these two populations.
在美国，脑癌在年轻人中发病率较高。美国军队的年龄结构比普通人群年轻，可能与脑癌相关的暴露因素不同。本研究旨在比较现役军人和普通人群中脑癌的发病率，为未来的病因学研究提供线索。同时还比较了各军种之间的发病率差异。
本研究的数据来自国防部的自动中央肿瘤登记处（ACTUR）和美国国家癌症研究所的监测、流行病学和最终结果 9（SEER-9）登记处。计算了 1990 年至 2013 年间 20-54 岁成年人中恶性神经上皮脑癌的年龄和性别调整发病率，并在这两个群体之间进行了比较，给出了发病率比（IRR）及其 95%置信区间（CI）。
现役人群中恶性神经上皮脑癌的年龄和性别调整发病率明显低于美国普通人群（IRR=0.62，95%CI，0.56-0.68）。现役人群中的发病率降低在男性、所有种族、20-44 岁的个体以及所有组织学亚型和评估的时间段中均观察到。各军种之间的发病率没有显著差异。
现役军人中神经上皮脑癌的发病率低于美国普通人群。本研究强调需要进一步研究，以提高我们对这两个群体之间脑癌发病率差异的认识。
