John P. Murtha Cancer Center Research Program, Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Eur J Cancer Prev. 2022 Mar 1;31(2):166-171. doi: 10.1097/CEJ.0000000000000698.
This study compared oral cavity and oropharyngeal cancer incidence rates and trends among men in the active-duty military and the general population of the USA.
Data were from the Department of Defenses' Automated Central Tumor Registry (ACTUR) and the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER-9) registries. Age-adjusted oral cavity and oropharyngeal cancer incidence rates among men aged 20-59 from 1990-2013 were compared between ACTUR and SEER populations.
The age-adjusted oral cancer incidence rate was lower in ACTUR than SEER (IRR = 0.89, 95% confidence interval (CI), 0.81-0.98). Incidence was lower in ACTUR for oral cavity cancer (IRR = 0.75, 95% CI, 0.66-0.89) and remained lower when stratified by age and race. ACTUR oropharyngeal cancer rates were higher than SEER among Whites (IRR = 1.19, 95% CI, 1.01-1.39) and men aged 40-59 (IRR = 1.18, 95% CI, 1.00-1.39). Oropharyngeal cancer increased for both populations over time, whereas oral cavity cancer increased in ACTUR but decreased in SEER.
Rates were lower in ACTUR than SEER for oral cavity, but not for oropharyngeal cancer. Temporal oral cancer incidence patterns differed between the two populations. This study provides clues for more research on possible variations between these two populations and related factors.
本研究比较了现役男性军人和美国一般人群口腔和口咽癌的发病率和趋势。
数据来自国防部的自动中央肿瘤登记处（ACTUR）和美国国家癌症研究所的监测、流行病学和最终结果（SEER-9）登记处。比较了 1990-2013 年间 ACTUR 和 SEER 人群中 20-59 岁男性的年龄调整口腔癌发病率。
ACTUR 的年龄调整口腔癌发病率低于 SEER（IRR=0.89，95%置信区间[CI]，0.81-0.98）。ACTUR 的口腔癌发病率较低（IRR=0.75，95%CI，0.66-0.89），并且按年龄和种族分层后仍然较低。ACTUR 的白人（IRR=1.19，95%CI，1.01-1.39）和 40-59 岁男性（IRR=1.18，95%CI，1.00-1.39）口咽癌发病率高于 SEER。两个人群的口咽癌发病率随时间增加，而 ACTUR 的口腔癌发病率增加，SEER 的口腔癌发病率减少。
ACTUR 的口腔癌发病率低于 SEER，但口咽癌发病率则不然。两个人群的口腔癌发病模式随时间而不同。本研究为进一步研究这两个人群之间的可能差异以及相关因素提供了线索。
