组织修复：以腱为导向的再生。

Tissue Repair: A Tendon-see to Regenerate.

机构信息

Regeneration Next, Duke University, Durham, NC 27710, USA; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Curr Biol. 2020 Sep 7;30(17):R1001-R1003. doi: 10.1016/j.cub.2020.06.089.

DOI:10.1016/j.cub.2020.06.089

PMID:32898487

Abstract

A new study establishes genetic tools to ablate tendon progenitor cells in zebrafish larvae, finding that larval tendons display high regenerative capacity. The authors employ this musculoskeletal repair model to explore the source of tendon progenitors by fate mapping and live imaging, as well as underlying molecular stimuli like BMP signaling.

摘要

一项新的研究建立了在斑马鱼幼虫中消融肌腱祖细胞的遗传工具，发现幼虫的肌腱具有很高的再生能力。作者利用这种肌肉骨骼修复模型，通过谱系追踪和活体成像来探索肌腱祖细胞的来源，以及 BMP 信号等潜在的分子刺激。