中国汉族人群中长链非编码RNA GAS5基因多态性与前列腺癌风险及预后的关联
Association of long-chain non-coding RNA GAS5 gene polymorphisms with prostate cancer risk and prognosis in Chinese Han population.
作者信息
Zhao Lisha, Zheng Weihong, Li Chen
机构信息
Department of Medical Oncology, Zhuji People's Hospital of Zhejiang Province, No. 9 Jianmin Road, Tao Zhu Street, Zhuji.
School of Life Science, Huzhou University, Huzhou Central Hospital, 759 Erhuan East Road, Huzhou.
出版信息
Medicine (Baltimore). 2020 Sep 4;99(36):e21790. doi: 10.1097/MD.0000000000021790.
BACKGROUND
To investigate the correlation between growth arrest-specific transcript 5 (GAS5) gene polymorphism and the risk and prognosis of prostate cancer in Chinese Han population.
METHODS
Sanger sequencing was used to analyze genotypes at the rs17359906 and rs1951625 loci of the GAS5 gene in 218 prostate cancer patients and 220 healthy controls. The follow-up period was from August 2016 to August 2019, and the relationships between GAS5 gene polymorphisms at the rs17359906 and rs1951625 loci and the recurrence-free survival rate of prostate cancer patients were analyzed.
RESULTS
GAS5 A-allele carriers at the rs17359906 locus were 3.44 times more likely to develop prostate cancer than G-allele carriers (95% confidence interval (CI): 2.38-4.96, P < .001). Carriers of the GAS5 A allele at the rs1951625 locus had a 1.40-fold higher risk of prostate cancer than carriers of the G allele (95% CI: 1.05-1.86, P = .027). Plasma prostate-specific antigen (PSA), body mass index (BMI), and rs17359906 and rs1951625 loci were independent risk factors for prostate cancer. GAS5 AA genotype and A-allele carriers (GA + AA) at the rs1951625 locus were significantly correlated with Gleason scores ≤7 (P < .05). GAS5 genes rs17359906 G > A and rs1951625 G > A were associated with high plasma PSA levels. The recurrence-free survival rate of patients with prostate cancer with AA genotype at the rs17359906 locus of GAS5 (66.67%) was significantly lower than that of the GA genotype (76.47%), whereas the GG genotype was the highest (91.96%), and the difference was statistically significant (P = .002). The recurrence-free survival rate of patients with prostate cancer with the AA genotype at the rs1951625 locus of GAS5 (75.00%) was significantly lower than that of the GA genotype (81.82%), whereas the GG genotype was the highest (87.76%) with a statistically significant difference (P = .025).
CONCLUSION
GAS5 rs17359906 G > A and rs1951625 G > A are significantly associated with an increased risk of prostate cancer and a reduction in three-year relapse-free survival.
背景
探讨生长停滞特异性转录本5（GAS5）基因多态性与中国汉族人群前列腺癌风险及预后的相关性。
方法
采用桑格测序法分析218例前列腺癌患者和220例健康对照者GAS5基因rs17359906和rs1951625位点的基因型。随访时间为2016年8月至2019年8月，分析rs17359906和rs1951625位点GAS5基因多态性与前列腺癌患者无复发生存率的关系。
结果
rs17359906位点GAS5 A等位基因携带者患前列腺癌的可能性是G等位基因携带者的3.44倍（95%置信区间（CI）：2.38 - 4.96，P<0.001）。rs1951625位点GAS5 A等位基因携带者患前列腺癌的风险比G等位基因携带者高1.40倍（95%CI：1.05 - 1.86，P = 0.027）。血浆前列腺特异性抗原（PSA）、体重指数（BMI）以及rs17359906和rs1951625位点是前列腺癌的独立危险因素。rs1951625位点GAS5 AA基因型和A等位基因携带者（GA + AA）与Gleason评分≤7显著相关（P<0.05）。GAS5基因rs17359906 G>A和rs1951625 G>A与血浆PSA水平升高有关。GAS5基因rs17359906位点AA基因型前列腺癌患者的无复发生存率（66.67%）显著低于GA基因型（76.47%），而GG基因型最高（91.96%），差异有统计学意义（P = 0.002）。GAS5基因rs1951625位点AA基因型前列腺癌患者的无复发生存率（75.00%）显著低于GA基因型（81.82%），而GG基因型最高（87.76%），差异有统计学意义（P = 0.025）。
结论
GAS5 rs17359906 G>A和rs1951625 G>A与前列腺癌风险增加及三年无复发生存率降低显著相关。
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