Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Int J Med Sci. 2019 Sep 20;16(11):1424-1429. doi: 10.7150/ijms.38080. eCollection 2019.
Down-regulation of Growth arrest-specific 5 (GAS5) is correlated with enhanced cell proliferation and poorer prognosis of prostate cancer. We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics. In this study, 579 prostate cancer patients who underwent robot-assisted radical prostatectomy and 579 healthy controls were included. The frequency of the allele del of rs145204276 were compared between the patients and the controls to evaluate the impact of tumor susceptibility and the correlation of clinicopathological variables. The results shown that patients who carries genotype ins/del or del/del at SNP rs145204276 showed decreased risk of pathological lymph node metastasis disease (OR=0.545, p=0.043) and risk of seminal vesicle invasion (OR=0.632, p=0.022) comparing to with genotype ins/ins. In the subgroup analysis of age, more significant risk reduction effects were noted over lymph node metastasis disease (OR=0.426, p=0.032) and lymphovascular invasion (OR=0.521, p=0.025). In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph node metastasis. This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis.
生长停滞特异性基因 5（GAS5）的下调与前列腺癌的细胞增殖增强和预后不良相关。我们旨在研究 GAS5 的变异 rs145204276 对前列腺癌易感性和临床病理特征的影响。在这项研究中，纳入了 579 例接受机器人辅助根治性前列腺切除术的前列腺癌患者和 579 例健康对照者。比较了 rs145204276 等位基因 del 的频率在患者和对照组之间，以评估肿瘤易感性的影响和临床病理变量的相关性。结果表明，携带 SNP rs145204276 基因型 ins/del 或 del/del 的患者，与基因型 ins/ins 的患者相比，患有病理淋巴结转移疾病的风险降低（OR=0.545，p=0.043）和精囊侵犯的风险降低（OR=0.632，p=0.022）。在年龄的亚组分析中，淋巴结转移疾病（OR=0.426，p=0.032）和血管侵犯（OR=0.521，p=0.025）的风险降低作用更为显著。总之，GAS5 基因 rs145204276 多态性基因型可以预测淋巴结转移的风险。这是首次报道 GAS5 基因多态性与前列腺癌预后的相关性的研究。
