Clayson D B
Bureau of Chemical Safety, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario.
Environ Health Perspect. 1988 Apr;77:93-7. doi: 10.1289/ehp.887793.
This paper suggests that not all chemicals shown to be carcinogenic in animals may exert this effect in humans exposed to much lower amounts of the chemical. It is possible that agents which differ in their effects in humans and animals may be identified through the application of Biological Risk Assessment to the experimental results. Chemicals tested in systems in which untreated animals develop high background yields of tumors or in which high-dose toxicity may be a critical factor in the induction of carcinogenesis are suggested as candidates requiring very careful consideration before their carcinogenicity in humans is assumed.
本文指出，并非所有在动物身上显示出致癌性的化学物质，在接触量低得多的人类身上都会产生这种影响。通过将生物风险评估应用于实验结果，有可能识别出在人类和动物身上作用不同的物质。对于那些在未处理动物中肿瘤背景发生率高的系统中进行测试的化学物质，或者在高剂量毒性可能是致癌作用关键因素的系统中进行测试的化学物质，在假定其对人类具有致癌性之前，建议将其作为需要非常谨慎考虑的候选物质。
