Ito N, Fukushima S, Hagiwara A, Shibata M, Ogiso T
J Natl Cancer Inst. 1983 Feb;70(2):343-52.
Butylated hydroxyanisole (BHA) was added at levels of 0.5 and 2.0% to the diet of inbred F344 rats for 2 years. The higher dose of BHA induced a significant increase in the incidence of papilloma and squamous cell carcinoma in both sexes. Both the higher and lower doses increased the incidences of hyperplasia of the forestomach, considered to be associated with neoplasias. The incidences of these neoplastic changes were dose-dependent. Neoplastic changes in other organs were not increased significantly by BHA. These results show that BHA is carcinogenic in the forestomach of F344 rats.
将叔丁基对羟基茴香醚（BHA）以0.5%和2.0%的水平添加到近交系F344大鼠的饮食中，持续2年。较高剂量的BHA使两性的乳头状瘤和鳞状细胞癌发病率显著增加。高剂量和低剂量均增加了前胃增生的发生率，前胃增生被认为与肿瘤形成有关。这些肿瘤性变化的发生率呈剂量依赖性。BHA未显著增加其他器官的肿瘤性变化。这些结果表明，BHA对F344大鼠的前胃具有致癌性。
