Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico.
CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse, CEDEX 4, France.
Molecules. 2020 Sep 4;25(18):4034. doi: 10.3390/molecules25184034.
A new class of phosphorus dendritic compounds (PDCs) having a cyclotriphosphazene (PN) core and decorated with six β-cyclodextrin (βCD) units, named PN-[O-CH-O-(CH)-βCD], where = 3 or 4 was designed, and the synthesis was performed using copper (I) catalyzed alkyne-azide cycloaddition (CuAAC). To obtain the complete substitution of the PN, two linkers consisting of an aromatic ring and an aliphatic chain of two different lengths were assessed. We found that, with both linkers, the total modification of the periphery was achieved. The two new obtained dendritic compounds presented a considerably high water solubility (>1 g/mL). The compounds comprised in this new class of PDCs are potential drug carrier candidates, since the conjugation of the βCD units to the PN core through the primary face will not only serve as surface cover but, also, provide them the faculty to encapsulate various drugs inside the βCDs cavities.
一类新型磷树枝状化合物（PDCs）被设计出来，其具有三聚磷腈（PN）核心并被六个β-环糊精（βCD）单元修饰，命名为 PN-[O-CH-O-(CH) -βCD]，其中=3 或 4。该化合物的合成采用铜（I）催化的叠氮-炔烃环加成（CuAAC）反应。为了获得 PN 的完全取代，评估了由一个芳环和两个不同长度的脂肪链组成的两种连接体。我们发现，使用这两种连接体，都实现了外围的完全修饰。这两种新获得的树枝状化合物具有相当高的水溶性（>1 g/mL）。这类新的 PDC 中的化合物是潜在的药物载体候选物，因为通过主面将βCD 单元与 PN 核心连接不仅可以作为表面覆盖物，还可以使它们具有将各种药物封装在βCD 空腔内的能力。
