Offenhäusser Andreas, Böcker-Meffert Simone, Decker Tanja, Helpenstein Rita, Gasteier Peter, Groll Jürgen, Möller Martin, Reska Anna, Schäfer Susanne, Schulte Petra, Vogt-Eisele Angela
Institute of Bio- and Nanosystems, Forschungszentrum Jülich, D-52425, Jülich, Germany.
Deutsches Wollforschungsinstitut at the RWTH Aachen, Pauwelsstr. 8, D-52074, Aachen, Germany.
Soft Matter. 2007 Feb 14;3(3):290-298. doi: 10.1039/b607615g.
The growth of neurons into networks of controlled geometry is of great interest in the field of cell-based biosensors, neuroelectronic circuits, neurological implants, pharmaceutical testing as well as fundamental biological questions about neuronal interactions. The precise control of the network architecture can be achieved by defined engineering of the surface material properties: this process is called neuronal cell patterning. Different techniques can be used to produce such surface patterns. We have chosen microcontact printing (μCP), because it is a comparatively simple and universal method for patterning biomolecules.
在基于细胞的生物传感器、神经电子电路、神经植入物、药物测试以及关于神经元相互作用的基础生物学问题等领域，神经元生长为具有可控几何形状的网络备受关注。通过对表面材料特性进行明确的工程设计，可以实现对网络架构的精确控制：这个过程称为神经元细胞图案化。可以使用不同的技术来产生这样的表面图案。我们选择了微接触印刷（μCP），因为它是一种相对简单且通用的生物分子图案化方法。
