Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Team Inflammation, Complement and Cancer, F-75006, Paris, France.
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Team Inflammation, Complement and Cancer, F-75006, Paris, France.
Semin Immunol. 2020 Apr;48:101407. doi: 10.1016/j.smim.2020.101407. Epub 2020 Sep 6.
NK cells orchestrate the tumor destruction and control metastasis in a coordinated way with other immune cells of the tumor microenvironment. However, NK cell infiltration in the tumor microenvironment is limited, and tumor cells have developed numerous mechanisms to escape NK cell attack. As a result, NK cells that have been able to infiltrate the tumors are exhausted, and metabolically and functionally impaired. Depending this impairment the prognostic and theranostic values of NK cells differ depending on the studies, the type of cancer, the stage of tumor and the nature of the tumor microenvironment. Extensive studies have been done to investigate different strategies to improve the NK cell function, and nowadays, a battery of therapeutic tools are being tested, with promising results.
自然杀伤 (NK) 细胞与肿瘤微环境中的其他免疫细胞协同作用，对肿瘤进行破坏和控制转移。然而，NK 细胞在肿瘤微环境中的浸润受到限制，肿瘤细胞已经发展出多种机制来逃避 NK 细胞的攻击。因此，能够浸润肿瘤的 NK 细胞已经衰竭，代谢和功能受损。根据这种损伤，NK 细胞的预后和治疗价值因研究、癌症类型、肿瘤分期和肿瘤微环境的性质而异。已经进行了广泛的研究来探索改善 NK 细胞功能的不同策略，如今，正在测试一系列有前途的治疗工具。
