Melnyk V
Department of Medicine, Oregon Health Sciences University.
Geriatrics. 1988 Jul;43(7):83-7, 90.
Despite what is known about pharmacokinetics in the elderly, there is little information regarding the relationship between age and disease-modifying antirheumatic agents or immunosuppressive drugs. Musculoskeletal diseases are common in the aging population, and the therapeutic use of potentially toxic pharmacologic agents, including immunosuppressives, is prevalent. A number of factors influence the potential for toxicity in this age group, including polypharmacy and age-related physiologic change. An overview of clinical pharmacologic factors in the elderly is presented, and available information on efficacy and toxicity of disease-modifying antirheumatics and immunosuppressives is reviewed.
尽管已知老年人的药代动力学情况，但关于年龄与改善病情抗风湿药或免疫抑制药物之间关系的信息却很少。肌肉骨骼疾病在老年人群中很常见，包括免疫抑制剂在内的潜在毒性药物的治疗性使用也很普遍。许多因素影响该年龄组的毒性可能性，包括多种药物并用和与年龄相关的生理变化。本文概述了老年人的临床药理学因素，并综述了有关改善病情抗风湿药和免疫抑制剂的疗效及毒性的现有信息。
