Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Cytokine Growth Factor Rev. 2021 Feb;57:64-72. doi: 10.1016/j.cytogfr.2020.08.004. Epub 2020 Aug 30.
Fibrosis leads to destruction of organ architecture accompanied by chronic inflammation and loss of function. Fibrosis affects nearly every organ in the body and accounts for ∼45% of total deaths worldwide. Over the past decade, tremendous progress has been made in understanding the basic mechanisms leading to organ fibrosis. However, we are limited with therapeutic options and there is a significant need to develop highly effective anti-fibrotic therapies. Recent advances in sequencing technologies have advanced the burgeoning field of epigenetics towards molecular understanding at a higher resolution. Here we provide a comprehensive review of the recent advances in chromatin regulatory processes, specifically DNA methylation, post-translational modification of histones, and chromatin remodeling complexes in kidney, liver and lung fibrosis. Although this research field is young, we discuss new strategies for potential therapeutic interventions for treating organ fibrosis.
纤维化导致器官结构破坏，伴随慢性炎症和功能丧失。纤维化几乎影响全身所有器官，占全球总死亡人数的约 45%。在过去的十年中，人们在理解导致器官纤维化的基本机制方面取得了巨大进展。然而，我们的治疗选择有限，因此非常有必要开发高效的抗纤维化疗法。测序技术的最新进展推动了新兴的表观遗传学领域朝着更高分辨率的分子理解方向发展。在这里，我们全面回顾了染色质调节过程（特别是 DNA 甲基化、组蛋白的翻译后修饰和染色质重塑复合物）在肾脏、肝脏和肺部纤维化中的最新进展。尽管这一研究领域还很年轻，但我们讨论了针对治疗器官纤维化的潜在治疗干预的新策略。
