Sutton B J
Department of Biophysics, Cell and Molecular Biology, King's College London, London, U.K.
Immunol Suppl. 1988;1:31-4.
Despite the wealth of information concerning the structure of the antibody-combining site and the interactions involved in the binding of small molecule haptens, there is considerable debate about the way in which antibodies recognize and bind to the surfaces of foreign proteins. Two recent crystallographic analyses of antibody molecules complexed with protein antigens have provided the first glimpses of the nature of this interaction at the atomic level.
尽管有大量关于抗体结合位点结构以及小分子半抗原结合过程中所涉及相互作用的信息，但对于抗体识别并结合外来蛋白质表面的方式仍存在相当大的争议。最近两项针对与蛋白质抗原形成复合物的抗体分子的晶体学分析，首次让我们在原子层面初步了解了这种相互作用的本质。
