Barish R J, Barish S V
Department of Radiology, NYU Medical Center, NY 10016.
Int J Radiat Oncol Biol Phys. 1988 Jun;14(6):1295-8. doi: 10.1016/0360-3016(88)90409-9.
For many years, the irradiation of small volumes of tissue in the brain to necrotizing doses has been investigated as a "non-invasive" alternative to neurosurgery. We propose a new system in which a precisely machined helmet serves as a multi-port focussed X-ray collimator when it is itself irradiated by a conventional medical linear accelerator run in the electron mode. When the collimator is attached to a stereotactic frame, the geometric accuracy of delivering small radiation fields to the brain is limited primarily by the accuracy of the stereotactic localization, and is relatively independent of the positional stability of the accelerator. Field sizes as small as two millimeters are readily achievable. The problem of low dose rate associated with these small fields is overcome by the use of high electron beam currents.
多年来，将脑部小体积组织照射至坏死剂量作为神经外科手术的“非侵入性”替代方法，一直受到研究。我们提出一种新系统，在该系统中，一个精确加工的头盔在由传统医用直线加速器以电子模式运行进行自身照射时，充当多端口聚焦X射线准直器。当准直器连接到立体定向框架上时，向脑部输送小辐射野的几何精度主要受立体定向定位精度的限制，并且相对独立于加速器的位置稳定性。很容易实现小至两毫米的野尺寸。通过使用高电子束电流，克服了与这些小野相关的低剂量率问题。
