Delannes M, Daly N J, Bonnet J, Sabatier J, Tremoulet M
Department of Radiotherapy, Hopital Purpan, Toulouse, France.
Int J Radiat Oncol Biol Phys. 1991 Aug;21(3):749-55. doi: 10.1016/0360-3016(91)90695-z.
Arteriovenous malformations (AVMs) and benign or low grade, small malignant tumors can be treated by stereotactic radiotherapy in a single fraction. This report describes a technique for stereotactic treatment of small lesions using conventional, fractionated, photon beam irradiation. The Laitinen's stereoadapter, non-invasive head frame was used. This device was tested for accuracy by serial mountings and found to be accurate within 1 mm. The accuracy of the dose delivered was within 2%. Adaptation of this device to the linear accelerator required the design of secondary circular collimators which decreased the penumbra from 3-4 mm to 2-3 mm. The dose fall off outside the target volume is steep enough when using two non-coplanar arcs (90 to 10% within 1 cm). Thermoluminescent dosimetry (TLD) in a humanoid phantom showed good correlation with the calculated dose. This system permits delivery of fractionated radiation therapy to small volumes, easily and accurately, under stereotactic conditions.
动静脉畸形（AVM）以及良性或低级别、小型恶性肿瘤可通过单次立体定向放射治疗进行治疗。本报告描述了一种使用常规分次光子束照射对小病灶进行立体定向治疗的技术。使用了莱蒂宁的立体适配器，即非侵入性头架。通过连续安装对该设备的准确性进行了测试，发现其精度在1毫米以内。所输送剂量的准确性在2%以内。将该设备适配到直线加速器需要设计二次圆形准直器，这将半影从3 - 4毫米减小到2 - 3毫米。使用两个非共面弧时，靶体积外的剂量下降足够陡峭（在1厘米内从90%降至10%）。在人体模型中的热释光剂量测定（TLD）与计算剂量显示出良好的相关性。该系统允许在立体定向条件下轻松、准确地对小体积病灶进行分次放射治疗。
