Hariz M I, Henriksson R, Löfroth P O, Laitinen L V, Säterborg N E
Department of Neurosurgery, University Hospital, Umeå, Sweden.
Radiother Oncol. 1990 Jan;17(1):57-72. doi: 10.1016/0167-8140(90)90049-3.
A new technique for fractionated stereotactic irradiation of intracranial lesions is described. The treatment is based on a versatile, non-invasive interface for stereotactic localization of the brain target imaged by computed tomography (CT), angiography or magnetic resonance tomography (MRT), and subsequent repetitive stereotactic irradiation of the target using a linear accelerator. The fractionation of the stereotactic irradiation was intended to meet the requirements of the basic principles of radiobiology. The radiophysical evaluation using phantoms, and the clinical results in a small number of patients, demonstrated a good reproducibility between repeated positionings of the target in the isocenter of the accelerator, and a high degree of accuracy in the treatment of brain lesions.
本文描述了一种用于颅内病变分次立体定向放射治疗的新技术。该治疗基于一种通用的、非侵入性的界面，用于对通过计算机断层扫描（CT）、血管造影或磁共振断层扫描（MRT）成像的脑靶区进行立体定向定位，随后使用直线加速器对靶区进行重复的立体定向照射。立体定向照射的分次旨在满足放射生物学基本原则的要求。使用模体进行的放射物理评估以及少数患者的临床结果表明，在加速器等中心对靶区进行重复定位时具有良好的可重复性，并且在治疗脑病变方面具有高度的准确性。
