The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Science at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, Anhui, China.
Angew Chem Int Ed Engl. 2020 Dec 1;59(49):21864-21869. doi: 10.1002/anie.202010009. Epub 2020 Oct 13.
Breathing process involves inhalation and exhalation of different gases in animals. The gas exchange of the breathing process plays a critical role in maintaining the physiological functions of living organisms. Although artificial breathing materials exhibiting volume expansion and contraction upon alternate exposure to different gases have been well explored, those being able to realize the gas exchange remain elusive. Herein, we report breathing micelles (BM) capable of inhaling nitric oxide (NO) and exhaling carbon monoxide (CO), both of which are endogenous gaseous signaling molecules. We demonstrate that BM can simultaneously scavenge overproduced NO and attenuate proinflammatory cytokines in lipopolysaccharide (LPS)-challenged macrophage cells. In vivo studies revealed that BM outperformed conventional nonsteroidal anti-inflammatory drugs such as dexamethasone (Dexa) in treatment of rheumatoid arthritis (RA) in adjuvant-induced arthritis (AIA) rats, likely due to the combinatorial effect of NO depletion, CO-mediated deactivation of inducible NO synthase (iNOS) and activation of heme oxygenase-1 (HO-1). This work provides new insights into artificial BM for potential biomedical applications.
呼吸过程涉及动物吸入和呼出不同的气体。呼吸过程中的气体交换在维持生物体的生理功能方面起着关键作用。尽管已经很好地研究了能够在交替暴露于不同气体时实现体积膨胀和收缩的人工呼吸材料，但能够实现气体交换的材料仍然难以捉摸。在这里，我们报告了能够吸入一氧化氮（NO）和呼出一氧化碳（CO）的呼吸胶束（BM），这两种气体都是内源性气体信号分子。我们证明，BM 可以同时清除过量产生的 NO 并减弱脂多糖（LPS）刺激的巨噬细胞中促炎细胞因子。体内研究表明，BM 在佐剂诱导关节炎（AIA）大鼠类风湿性关节炎（RA）的治疗中优于传统的非甾体抗炎药，如地塞米松（Dexa），这可能是由于 NO 耗竭、CO 介导的诱导型一氧化氮合酶（iNOS）失活和血红素加氧酶-1（HO-1）激活的组合作用。这项工作为人工 BM 在潜在的生物医学应用中提供了新的见解。
