Rong Fan, Wang Tengjiao, Zhou Qian, Peng Haowei, Yang Jingtian, Fan Quli, Li Peng
Frontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, Shaanxi, 710072, PR China.
Honors College, Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, Shaanxi, 710072, PR China.
Bioact Mater. 2022 Apr 13;19:198-216. doi: 10.1016/j.bioactmat.2022.03.043. eCollection 2023 Jan.
Hydrogen sulfide (HS) plays an important role in regulating various pathological processes such as protecting mammalian cell from harmful injuries, promoting tissue regeneration, and regulating the process of various diseases caused by physiological disorders. Studies have revealed that the physiological effects of HS are highly associated with its concentrations. At relatively low concentration, HS shows beneficial functions. However, long-time and high-dose donation of HS would inhibit regular biological process, resulting in cell dysfunction and apoptosis. To regulate the dosage of HS delivery for precision medicine, HS delivery systems with intelligent characteristics were developed and a variety of biocompatibility polymers have been utilized to establish intelligent polymeric HS delivery systems, with the abilities to specifically target the lesions, smartly respond to pathological microenvironments, as well as real-timely monitor HS delivery and lesion conditions by incorporating imaging-capable moieties. In this review, we focus on the design, preparation, and therapeutic applications of intelligent polymeric HS delivery systems in cardiovascular therapy, inflammatory therapy, tissue regenerative therapy, cancer therapy and bacteria-associated therapy. Strategies for precise HS therapies especially imaging-guided HS theranostics are highlighted. Since HS donors with stimuli-responsive characters are vital components for establishing intelligent HS delivery systems, the development of HS donors is also briefly introduced.
硫化氢（HS）在调节各种病理过程中发挥着重要作用，如保护哺乳动物细胞免受有害损伤、促进组织再生以及调节由生理紊乱引起的各种疾病的进程。研究表明，HS的生理效应与其浓度高度相关。在相对较低的浓度下，HS表现出有益的功能。然而，长时间和高剂量给予HS会抑制正常的生物过程，导致细胞功能障碍和凋亡。为了在精准医学中调节HS递送的剂量，开发了具有智能特性的HS递送系统，并利用了多种生物相容性聚合物来建立智能聚合物HS递送系统，这些系统能够特异性地靶向病变部位，智能地响应病理微环境，并通过结合具有成像能力的部分实时监测HS递送和病变情况。在这篇综述中，我们重点关注智能聚合物HS递送系统在心血管治疗、炎症治疗、组织再生治疗、癌症治疗和细菌相关治疗中的设计、制备和治疗应用。强调了精确HS治疗的策略，特别是成像引导的HS诊疗方法。由于具有刺激响应特性的HS供体是建立智能HS递送系统的关键组成部分，因此也简要介绍了HS供体的发展情况。
