Department of Centralised Molecular Diagnostics, Apollo Hospitals, Chennai, Tamil Nadu, India.
Department of Hematology, Apollo Hospitals, Chennai, Tamil Nadu, India.
Cancer Rep (Hoboken). 2020 Dec;3(6):e21290. doi: 10.1002/cnr2.1290. Epub 2020 Sep 9.
Recurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR-ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR -ABL - is the commonest recurrent abnormality whereas, IgH rearrangements are rare.
Aim of this study was to identify common recurrent genetic abnormalities in adult B ALL and study their association with hematological findings.
Bone marrow and peripheral blood from patients with B acute lymphoblastic leukemia were analyzed for complete blood counts, bone marrow morphology and cytogenetic abnormalities. The study group was divided into smaller groups based on cytogenetic abnormalities. Hematological parameters and presence of recurrent genetic abnormalities was compared across age groups and gender by non parametric tests.
BCR-ABL positive group had a higher leukocyte count than BCR-ABL negative group. Among groups 1 to 5, group 1 with gains of chromosomes was associated with leucopenia and higher age at presentation. BCR-ABL is commonest recurrent abnormality followed by IgH rearrangements.
Patients with gains of chromosomes alone have low total leukocyte counts at presentation.
复发性遗传异常影响 B 淋巴母细胞白血病的预后。BCR-ABL 重排与较高的白细胞计数和较年长的发病年龄有关。在成年人中，BCR-ABL-是最常见的复发性异常，而 IgH 重排则很少见。
本研究旨在鉴定成人 B 急性淋巴细胞白血病中常见的复发性遗传异常，并研究其与血液学发现的关系。
对 B 急性淋巴细胞白血病患者的骨髓和外周血进行分析，包括全血细胞计数、骨髓形态学和细胞遗传学异常。根据细胞遗传学异常将研究组分为较小的组。通过非参数检验比较不同年龄组和性别的血液学参数和复发性遗传异常的存在。
BCR-ABL 阳性组的白细胞计数高于 BCR-ABL 阴性组。在组 1 至 5 中，染色体增益组与白细胞减少和发病年龄较大有关。BCR-ABL 是最常见的复发性异常，其次是 IgH 重排。
仅染色体增益的患者在发病时总白细胞计数较低。
