Brown D F, Warner M, Taylor C E, Warren R E
Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge.
J Clin Pathol. 1988 Jun;41(6):671-5. doi: 10.1136/jcp.41.6.671.
A total of 3347 blood cultures from patients in all hospital wards were examined on a Malthus microbiological growth analyser and by a conventional system. There was no significant difference in the total numbers of positive cultures of clinical importance between the two systems (p greater than 0.05). Staphylococcus aureus, however, was isolated more often by the conventional method (p less than 0.05). Failure of the automatic detection routine limited the potential of the Malthus system for earlier detection of positive cultures. Daily visual examination of Malthus curves and subculture of bottles not promptly attached to the apparatus were necessary to avoid missing some positive cultures. False positive rates were 13% for the Malthus system and 2% for the conventional system. The contamination rate was considerably lower in the Malthus system (p less than 0.001). Further development would be necessary for the apparatus to be acceptable for routine screening of blood cultures.
对来自医院所有病房患者的3347份血培养样本，使用马尔萨斯微生物生长分析仪和传统系统进行了检测。两种系统在具有临床意义的阳性培养物总数上无显著差异（p>0.05）。然而，金黄色葡萄球菌通过传统方法分离出的频率更高（p<0.05）。自动检测程序的失败限制了马尔萨斯系统早期检测阳性培养物的潜力。为避免漏检一些阳性培养物，需要每天对马尔萨斯曲线进行目视检查，并对未及时连接到仪器的培养瓶进行传代培养。马尔萨斯系统的假阳性率为13%，传统系统为2%。马尔萨斯系统的污染率显著更低（p<0.001）。该仪器要用于血培养的常规筛查，还需要进一步改进。
