Toll 样受体参与血压调节的性别差异。
Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation.
机构信息
*Graduate Program in Biological Sciences, Federal University of Goiás, Goiânia, Brazil; †Institute of Health Sciences and Health, Universidad Federal De Mato Grosso, Barra Do Garcas, Brazil; and ‡Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA.
出版信息
J Cardiovasc Pharmacol. 2020 Sep;76(3):255-266. doi: 10.1097/FJC.0000000000000869.
Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood pressure. The incidence of hypertension is higher in men, and it increases in postmenopausal women. In fact, premenopausal women are protected from cardiovascular disease compared with age-matched men, and it is well established that this protective effect is lost with menopause. However, the molecular mechanisms underlying this protection in women are unknown. Whether or not it could be related to differential activation of the innate immune system remains to be elucidated. This review focuses on (1) the differences between men and women in TLR activation and (2) whether TLR activation may influence the regulation of blood pressure in a sex-dependent manner.
Toll 样受体（TLRs）在先天免疫系统中发挥重要作用，最近的研究表明它们还参与了血压的调节。男性高血压的发病率更高，而绝经后女性的发病率则会上升。事实上，与同龄男性相比，绝经前女性患心血管疾病的风险较低，而这种保护作用在绝经后会消失。然而，女性具有这种保护作用的分子机制尚不清楚。这种保护作用是否与先天免疫系统的激活存在差异有关仍有待阐明。这篇综述重点关注（1）TLR 激活在男性和女性之间的差异，以及（2）TLR 激活是否可能以性别依赖的方式影响血压的调节。
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