School of Pharmacy, University of Ghana, College of Health Sciences, Accra, Ghana.
Department of Surgery, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.
J Infect Dev Ctries. 2020 Aug 31;14(8):861-868. doi: 10.3855/jidc.11259.
This study sought to identify the association of antibiotic prescribing and the risk of antibiotic-associated diarrhoea (AAD) in Korle Bu Teaching Hospital (KBTH) in Ghana.
Patients from the Male Urology Ward and Treatment Room of the Surgical Department of KBTH were followed up over three months to determine if they had experienced any unusual diarrhoeal illness after antibiotic therapy. 81 eligible patients (adults) were included in the study but a total of 70 patients (mean age of 56.71 years) were successfully followed up during the study period.
The top conditions presented by patients were urological infection (66.7%), cancer (15.3%) and leg ulcer (18.1%). Ciprofloxacin (50%) and ceftriaxone (28.5%) were the most prescribed antibiotics. Eleven patients (more than 1 in 7) developed diarrhoea that could be associated with their use of antibiotics. The occurrence of AAD was significantly associated with type of antibiotic used by patient. 73% of patients who developed symptoms of AAD had received Clindamycin. Risk of AAD was not significantly associated with age and comorbidities.
The rate of AAD in the Male Urology Ward and the Treatment Room of the Surgical Department of KBTH during the period of this study was 15.7%. Clindamycin was identified as the most implicated antibiotic.
本研究旨在确定抗生素使用与加纳科托努教学医院（KBTH）抗生素相关性腹泻（AAD）风险之间的关联。
对 KBTH 外科部门男性泌尿科病房和治疗室的患者进行了为期三个月的随访，以确定他们在接受抗生素治疗后是否出现任何异常腹泻疾病。本研究共纳入 81 名符合条件的患者（成人），但在研究期间共成功随访了 70 名患者（平均年龄为 56.71 岁）。
患者的主要疾病包括尿路感染（66.7%）、癌症（15.3%）和腿部溃疡（18.1%）。环丙沙星（50%）和头孢曲松（28.5%）是最常开的抗生素。有 11 名患者（超过 1/7）出现腹泻，可能与使用抗生素有关。AAD 的发生与患者使用的抗生素类型显著相关。出现 AAD 症状的患者中，73%使用了克林霉素。AAD 的风险与年龄和合并症无显著相关性。
在本研究期间，KBTH 外科部门男性泌尿科病房和治疗室的 AAD 发生率为 15.7%。克林霉素被确定为最相关的抗生素。
