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木犀草素在糖皮质激素诱导的股骨头坏死中的保护作用

The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.

作者信息

Yan Zijian, Zhan Jingdi, Qi Weihui, Lin Jian, Huang Yijiang, Xue Xinghe, Pan Xiaoyun

机构信息

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthpaedics, Wenzhou, China.

出版信息

Front Pharmacol. 2020 Aug 12;11:1195. doi: 10.3389/fphar.2020.01195. eCollection 2020.

DOI:10.3389/fphar.2020.01195
PMID:32903480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7435053/
Abstract

Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess multiple pharmacological properties including anticancer, antioxidant, antiapoptosis, and antiinflammatory properties. However, whether Lut has a protective effect on the development of GIONFH remains unclear. In this study, we evaluated the effect of Lut on Dexamethasone (Dex)-induced STAT1/caspase3 pathway and evaluated GIONFH model . , Lut inhibited the upregulation of Dex-induced phospho-STAT1, cleaved caspase9, and cleaved caspase3. In addition, Lut inhibited Dex-induced expression of Bax and cytochrome c and increased the expression of B cell lymphoma-2(Bcl-2). , Lut decreased the proportion of empty lacunae in rats with GIONFH. Taken together, these findings indicate that Lut may have therapeutic potential in the treatment of GIONFH. Further, this effect might be achieved by suppressing mitochondrial apoptosis of osteoblasts inhibition of STAT1 activity.

摘要

糖皮质激素诱导的股骨头坏死（GIONFH）是一种常见的非创伤性骨坏死类型。若不及时治疗，最终会导致软骨下骨结构塌陷。木犀草素（Lut）是从骨碎补中提取的一种化合物，据报道具有多种药理特性，包括抗癌、抗氧化、抗凋亡和抗炎特性。然而，Lut对GIONFH的发展是否具有保护作用仍不清楚。在本研究中，我们评估了Lut对地塞米松（Dex）诱导的STAT1/半胱天冬酶3通路的影响，并评估了GIONFH模型。结果表明，Lut抑制了Dex诱导的磷酸化STAT1、裂解的半胱天冬酶9和裂解的半胱天冬酶3的上调。此外，Lut抑制了Dex诱导的Bax和细胞色素c的表达，并增加了B细胞淋巴瘤-2（Bcl-2）的表达。此外，Lut降低了GIONFH大鼠中空骨陷窝的比例。综上所述，这些发现表明Lut在治疗GIONFH方面可能具有治疗潜力。此外，这种作用可能是通过抑制成骨细胞的线粒体凋亡和抑制STAT1活性来实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/34b8f5149427/fphar-11-01195-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/65f2c1aa54e8/fphar-11-01195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/77b8373a9e6e/fphar-11-01195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/a15f0e0ffe26/fphar-11-01195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/4d2c2e8759b6/fphar-11-01195-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/4ac7c4941d36/fphar-11-01195-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/89110d2eeabb/fphar-11-01195-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/34b8f5149427/fphar-11-01195-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/65f2c1aa54e8/fphar-11-01195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/77b8373a9e6e/fphar-11-01195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/a15f0e0ffe26/fphar-11-01195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/4d2c2e8759b6/fphar-11-01195-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/4ac7c4941d36/fphar-11-01195-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/89110d2eeabb/fphar-11-01195-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f57/7435053/34b8f5149427/fphar-11-01195-g007.jpg

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本文引用的文献

[1]
Antagonistic Efficacy of Luteolin against Lead Acetate Exposure-Associated with Hepatotoxicity is Mediated via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activities.

Antioxidants (Basel). 2019-12-21

[2]
Liposomal encapsulation of silver nanoparticles (AgNP) improved nanoparticle uptake and induced redox imbalance to activate caspase-dependent apoptosis.

Apoptosis. 2020-2

[3]
Haem oxygenase-1 induction prevents glucocorticoid-induced osteoblast apoptosis through activation of extracellular signal-regulated kinase1/2 signalling pathway.

J Orthop Translat. 2019-4-28

[4]
Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway.

Photochem Photobiol. 2020-1

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BMC Musculoskelet Disord. 2019-10-15

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Exosomes derived from Wharton's jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR-21-PTEN-AKT signalling pathway.

Int J Biol Sci. 2019-7-20

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Luteolin exhibits anti-breast cancer property through up-regulating miR-203.

Artif Cells Nanomed Biotechnol. 2019-12

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Med Sci Monit. 2019-8-1

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Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses.

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