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马哮喘:当前的认识与未来方向

Equine Asthma: Current Understanding and Future Directions.

作者信息

Couetil Laurent, Cardwell Jacqueline M, Leguillette Renaud, Mazan Melissa, Richard Eric, Bienzle Dorothee, Bullone Michela, Gerber Vinzenz, Ivester Kathleen, Lavoie Jean-Pierre, Martin James, Moran Gabriel, Niedźwiedź Artur, Pusterla Nicola, Swiderski Cyprianna

机构信息

College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.

Department of Pathobiology and Population Sciences, Royal Veterinary College, London, United Kingdom.

出版信息

Front Vet Sci. 2020 Jul 30;7:450. doi: 10.3389/fvets.2020.00450. eCollection 2020.

Abstract

The 2019 Havemeyer Workshop brought together researchers and clinicians to discuss the latest information on Equine Asthma and provide future research directions. Current clinical and molecular asthma phenotypes and endotypes in humans were discussed and compared to asthma phenotypes in horses. The role of infectious and non-infectious causes of equine asthma, genetic factors and proposed disease pathophysiology were reviewed. Diagnostic limitations were evident by the limited number of tests and biomarkers available to field practitioners. The participants emphasized the need for more accessible, standardized diagnostics that would help identify specific phenotypes and endotypes in order to create more targeted treatments or management strategies. One important outcome of the workshop was the creation of the Equine Asthma Group that will facilitate communication between veterinary practice and research communities through published and easily accessible guidelines and foster research collaboration.

摘要

2019年哈夫迈耶研讨会汇聚了研究人员和临床医生,共同探讨马哮喘的最新信息,并提供未来的研究方向。会上讨论了人类当前的临床和分子哮喘表型及内型,并与马的哮喘表型进行了比较。回顾了马哮喘的感染性和非感染性病因、遗传因素以及提出的疾病病理生理学。现场从业者可用的检测和生物标志物数量有限,这凸显了诊断方面的局限性。与会者强调需要更易于获取的标准化诊断方法,以帮助识别特定的表型和内型,从而制定更具针对性的治疗或管理策略。该研讨会的一项重要成果是成立了马哮喘小组,该小组将通过发布且易于获取的指南促进兽医实践和研究团体之间的交流,并推动研究合作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fff/7438831/e94139cd045d/fvets-07-00450-g0001.jpg

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