Department of Microbiology and Immunology, The University of Melbourne and The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Department of Surgery, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
Front Immunol. 2020 Jul 31;11:1549. doi: 10.3389/fimmu.2020.01549. eCollection 2020.
The brain is considered an immune privileged site due to the high selectivity of the blood-brain barrier which restricts the passage of molecules and cells into the brain parenchyma. Recent studies have highlighted active immunosurveillance mechanisms in the brain. Here we review emerging evidence for the contribution of innate lymphoid cells (ILCs) including natural killer (NK) cells to the immunosurveillance of brain cancers focusing on glioblastoma, one of the most aggressive and most common malignant primary brain tumors diagnosed in adults. Moreover, we discuss how the local tissue microenvironment and unique cellular interactions influence ILC functions in the brain and how these interactions might be successfully harnessed for cancer immunotherapy using insights gained from the studies of autoimmunity, aging, and CNS injury.
大脑被认为是一个免疫特惠部位，这是由于血脑屏障的高选择性，它限制了分子和细胞进入脑实质。最近的研究强调了大脑中主动的免疫监视机制。在这里，我们综述了先天淋巴细胞（ILC）包括自然杀伤（NK）细胞在脑癌免疫监视中的新证据，重点是胶质母细胞瘤，这是成年人中诊断出的最具侵袭性和最常见的恶性原发性脑肿瘤之一。此外，我们还讨论了局部组织微环境和独特的细胞相互作用如何影响大脑中 ILC 的功能，以及如何利用自身免疫、衰老和中枢神经系统损伤研究中获得的见解，成功地将这些相互作用用于癌症免疫治疗。
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