Li Xin, Gou Wenting, Zhang Xiaoqin
Department of Pathology, School of Medicine, South China University of Technology, Guangzhou 510006, China.
Brain Sci. 2024 Jul 9;14(7):687. doi: 10.3390/brainsci14070687.
Glioblastoma is the most common and malignant primary brain tumor, with high morbidity and mortality. Despite an aggressive, multimodal treatment regimen, including surgical resection followed by chemotherapy and radiotherapy, the prognosis of glioblastoma patients remains poor. One formidable challenge to advancing glioblastoma therapy is the complexity of the tumor microenvironment. The tumor microenvironment of glioblastoma is a highly dynamic and heterogeneous system that consists of not only cancerous cells but also various resident or infiltrating inflammatory cells. These inflammatory cells not only provide a unique tumor environment for glioblastoma cells to develop and grow but also play important roles in regulating tumor aggressiveness and treatment resistance. Targeting the tumor microenvironment, especially neuroinflammation, has increasingly been recognized as a novel therapeutic approach in glioblastoma. In this review, we discuss the components of the tumor microenvironment in glioblastoma, focusing on neuroinflammation. We discuss the interactions between different tumor microenvironment components as well as their functions in regulating glioblastoma pathogenesis and progression. We will also discuss the anti-tumor microenvironment interventions that can be employed as potential therapeutic targets.
胶质母细胞瘤是最常见且恶性程度最高的原发性脑肿瘤，发病率和死亡率都很高。尽管采用了积极的多模式治疗方案，包括手术切除，随后进行化疗和放疗，但胶质母细胞瘤患者的预后仍然很差。推进胶质母细胞瘤治疗面临的一个巨大挑战是肿瘤微环境的复杂性。胶质母细胞瘤的肿瘤微环境是一个高度动态且异质性的系统，不仅由癌细胞组成，还包括各种驻留或浸润的炎症细胞。这些炎症细胞不仅为胶质母细胞瘤细胞的发育和生长提供了独特的肿瘤环境，还在调节肿瘤侵袭性和治疗抗性方面发挥重要作用。针对肿瘤微环境，特别是神经炎症，越来越被认为是胶质母细胞瘤的一种新型治疗方法。在本综述中，我们讨论了胶质母细胞瘤肿瘤微环境的组成部分，重点是神经炎症。我们讨论了不同肿瘤微环境成分之间的相互作用及其在调节胶质母细胞瘤发病机制和进展中的作用。我们还将讨论可作为潜在治疗靶点的抗肿瘤微环境干预措施。
