Major Erin, Dutson Thomas, Moshirfar Majid
Southern California College of Optometry, Marshall B. Ketchum University, Fullerton, CA, USA.
Hoopes Vision, Draper, UT, USA.
Clin Optom (Auckl). 2020 Aug 25;12:129-133. doi: 10.2147/OPTO.S217645. eCollection 2020.
To determine the current scope of practice with regards to cycloplegic examinations, specifically in the pediatric population.
A comprehensive literature review was conducted using PubMed, ScienceDirect, Elsevier, and Google Scholar databases using keywords such as "cyclopentolate"; "tropicamide"; "pediatric"; "cycloplegia"; "atropine"; and "cycloplegic" from inception to October 2019.
Atropine has the strongest cycloplegic effect and is recommended for cases of large accommodative esotropia. Because of the undesired side effects and risks from atropine, cyclopentolate has been found to offer a very effective cycloplegia even for moderate to high hyperopia and has become the standard of care for traditional pediatric cycloplegic exams. Tropicamide has also been shown to offer adequate cycloplegia with less toxicity and side effects. Of all agents, tropicamide presents the least side effects and toxicity, whereas atropine presents the greatest. Cyclopentolate is a very safe cycloplegic agent that has risk of toxicity which increases with higher doses and concentrations.
The American Optometric Association's current pediatric cycloplegic guidelines have proven both safe and effective, as they recommend a conservative approach of using cyclopentolate 0.5% in infants and cyclopentolate 1% in those older than one-year old to avoid undesired side effects. Topical ophthalmic drops and spray instillation have both proved equally efficacious and therefore each have their place within a clinical setting. Using Cycolmydril under six months old and cyclopentolate 1% over 6 months old as recommended by the AAO, also provides a safe and effective guideline for cycloplegic examinations within the pediatric population.
确定目前关于睫状肌麻痹检查的实践范围,特别是在儿科人群中的情况。
使用PubMed、ScienceDirect、爱思唯尔和谷歌学术数据库进行全面的文献综述,使用的关键词如“环喷托酯”;“托吡卡胺”;“儿科”;“睫状肌麻痹”;“阿托品”;以及“睫状肌麻痹剂”,检索时间从数据库建立到2019年10月。
阿托品具有最强的睫状肌麻痹作用,推荐用于治疗大度数调节性内斜视。由于阿托品存在不良副作用和风险,已发现环喷托酯即使对于中度至高度远视也能产生非常有效的睫状肌麻痹作用,并且已成为传统儿科睫状肌麻痹检查的标准治疗方法。托吡卡胺也已被证明能提供足够的睫状肌麻痹作用,且毒性和副作用较小。在所有药物中,托吡卡胺的副作用和毒性最小,而阿托品的副作用和毒性最大。环喷托酯是一种非常安全的睫状肌麻痹剂,但随着剂量和浓度的增加,其毒性风险也会增加。
美国验光协会目前的儿科睫状肌麻痹指南已被证明既安全又有效,因为它们推荐了一种保守的方法,即婴儿使用0.5%的环喷托酯,一岁以上儿童使用1%的环喷托酯,以避免不良副作用。局部眼药水和喷雾滴注已被证明同样有效,因此在临床环境中都有各自的应用场景。按照美国眼科学会的建议,六个月以下使用赛克罗迈德,六个月以上使用1%的环喷托酯,也为儿科人群的睫状肌麻痹检查提供了安全有效的指导原则。